ArticleJournal of clinical immunology2000
IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease.
Article in Journal of clinical immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 76 citations in OpenAlex.
- A Chronic Psoriasis Model Using Long-Term Imiquimod Application in IL-10-Deficient Mice: Recapitulating Skin Inflammation, Comorbidities, and Gut-Skin Axis Alterations.Annals of dermatology · 2025Article
- Single-cell transcriptomic characterization of microscopic colitis.Nature communications · 2025Article
- Peripheral monocytes from Crohn's disease patients retain functional responsiveness to GM-CSF during active disease.Frontiers in immunology · 2025Article
- The role of interleukin-22 in mammalian intestinal homeostasis: Friend and foe.Immunity, inflammation and disease · 2024Review
- Mucosal Interleukin-10 depletion in steroid-refractory Crohn's disease patients.Immunity, inflammation and disease · 2022Article
- Impact of Microbial Metabolites on Microbiota-Gut-Brain Axis in Inflammatory Bowel Disease.International journal of molecular sciences · 2021Review
- Tryptophan Metabolites Along the Microbiota-Gut-Brain Axis: An Interkingdom Communication System Influencing the Gut in Health and Disease.International journal of tryptophan research : IJTR · 2020Review
- Molecular and functional heterogeneity of IL-10-producing CD4Nature communications · 2018Article
- Frequency of CD4+CD161+ T Cell and Interleukin-10 Expression in Inflammatory Bowel Diseases.Acta histochemica et cytochemica · 2017Article
- Swimming attenuates inflammation, oxidative stress, and apoptosis in a rat model of dextran sulfate sodium-induced chronic colitis.Oncotarget · 2017Article
- Changes of cytokine levels in a mouse model of post-infectious irritable bowel syndrome.BMC gastroenterology · 2015Article
- CFTR Knockdown induces proinflammatory changes in intestinal epithelial cells.Journal of inflammation (London, England) · 2015Article
- Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family.Mediators of inflammation · 2015Review
- Article
- Why interleukin-10 supplementation does not work in Crohn's disease patients.World journal of gastroenterology · 2013Review
- Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease.World journal of gastroenterology · 2011Review
- Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.BMC medical genomics · 2010Article
- The gut feeling of Treg cells: IL-10 is the silver lining during colitis.Nature immunology · 2009Article
- The IL-10R1 S138G loss-of-function allele and ulcerative colitis.Genes and immunity · 2009Article
- Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease.Gene therapy · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-10 (IL-10) deficiency in gene knockout mice causes chronic enterocolitis. We hypothesized that inflammation in human inflammatory bowel disease might result from innate alterations in the IL-10 pathway. Serum, supernatants, and mRNA of peripheral blood mononuclear cells (PBMC) and lamina propria mononuclear cells (LPMC) derived from inflamed (LPMC-i) and noninflamed colonic mucosa (LPMC-ni) were collected from patients with Crohn's colitis, ulcerative colitis, and controls. IL-10 protein concentrations and IL-10 mRNA were examined in response to PMA/CD3 or PHA stimulation. The response to rhIL-10 was assessed by inhibition of tumor necrosis factor-alpha (TNF-alpha), IL-6, and interferon-gamma (IFN-gamma) production. Serum IL-10 levels of inflammatory bowel disease (IBD) patients were within the normal range. IL-10 concentrations in supernatants from LPMC-i were significantly lower than from LPMC-ni or PBMC. No difference was seen between samples from ulcerative colitis and Crohn's disease. IL-10 mRNA was detected in 0/4 LPMC-i samples compared to 1/6 LPMC-ni and 6/6 PBMC. RhIL-10 inhibited TNF-alpha, IL-6, and IFN-gamma synthesis in PBMC. This effect was strongly diminished in LPMC. Disease-specific alterations were not detected. Our data suggest that LPMC derived from inflamed colonic mucosa have a reduced ability to produce and to respond to rhIL-10. A disease-specific alteration in the IL-10 pathway, however, was not found.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.