ArticleProceedings of the National Academy of Sciences of the United States of America2000
Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 67 citations in OpenAlex.
- Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression.International journal of molecular sciences · 2022Review
- Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors.PLoS biology · 2020Article
- TGF-β Family Signaling in Early Vertebrate Development.Cold Spring Harbor perspectives in biology · 2018Review
- The ved protein patterning in zebrafish embryos.Stem cell investigation · 2018Article
- Vertebrate Axial Patterning: From Egg to Asymmetry.Advances in experimental medicine and biology · 2017Review
- Expression ofStem cell investigation · 2017Article
- Split top: a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis.Development (Cambridge, England) · 2016Article
- vox homeobox gene: a novel regulator of midbrain-hindbrain boundary development in medaka fish?Development genes and evolution · 2016Article
- Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes.Seminars in cell & developmental biology · 2015Review
- Spatial reconstruction of single-cell gene expression data.Nature biotechnology · 2015Article
- The integrator complex subunit 6 (Ints6) confines the dorsal organizer in vertebrate embryogenesis.PLoS genetics · 2013Article
- Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis.PloS one · 2011Article
- Lnx-2b restricts gsc expression to the dorsal mesoderm by limiting Nodal and Bozozok activity.Biochemical and biophysical research communications · 2010Article
- Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like.Nature cell biology · 2009Article
- Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm.Development (Cambridge, England) · 2008Article
- Zebrafish bmp4 functions during late gastrulation to specify ventroposterior cell fates.Developmental biology · 2007Article
- Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling.Developmental biology · 2007Article
- The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning.The EMBO journal · 2007Article
- Zebrafish GADD45beta genes are involved in somite segmentation.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Maternal induction of ventral fate by zebrafish radar.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
During zebrafish development, zygotic gene expression initiated at the midblastula transition converts maternal information on embryo polarity into a transcriptional read-out. Expression of a homeobox gene, vega1, is activated at midblastula transition in all blastomeres, but is down-regulated dorsally before gastrulation. Ubiquitous expression of vega1 is maintained in bozozok mutants, in which the dorsal-specific homeobox gene bozozok/dharma (boz/dha) is disrupted and organizer formation is impaired. Vega1 inhibits expression of boz/dha and organizer-specific genes, and causes ventralization resulting in a headless phenotype. In contrast, VP16-vega1, a fusion including the Vega1 homeodomain and VP16 activation domain, elicits ectopic expression of organizer genes and suppresses several aspects of the boz mutant phenotype. We propose that boz/dha-dependent down-regulation of vega1 in the dorsal region is an early essential step in organizer formation in zebrafish.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.