ArticleProceedings of the National Academy of Sciences of the United States of America2000
Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target.International journal of molecular sciences · 2022Review
- Characterization of Integrin αIIbβ3-Mediated Outside-in Signaling by Protein Kinase Cδ in Platelets.International journal of molecular sciences · 2020Article
- Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting.Journal of hematology & oncology · 2019Review
- Integrin αBlood · 2017Review
- Binding of CIB1 to the αIIb tail of αIIbβ3 is required for FAK recruitment and activation in platelets.PloS one · 2017Article
- Mitochondrial calcium and reactive oxygen species regulate agonist-initiated platelet phosphatidylserine exposure.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Platelet biogenesis and functions require correct protein O-glycosylation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Integrin signalling and function in immune cells.Immunology · 2012Review
- Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.The Journal of experimental medicine · 2012Article
- Understanding signal integration through targeted mutations of an adapter protein.FEBS letters · 2010Article
- Immunopathologies linked to integrin signalling.Seminars in immunopathology · 2010Review
- Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76.Cold Spring Harbor perspectives in biology · 2010Review
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- The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells.Molecular and cellular biology · 2009Article
- SLP-76 couples Syk to the osteoclast cytoskeleton.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function.Immune network · 2009Article
- Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.Journal of thrombosis and haemostasis : JTH · 2008Article
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- Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.The Journal of experimental medicine · 2008Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice deficient in the hematopoietic cell-specific adapter protein SLP-76 demonstrate a failure of T cell development and fetal hemorrhage. Although SLP-76-deficient platelets manifest defective collagen receptor signaling, this alone may not explain the observed bleeding diathesis. Because alpha IIb beta 3, the platelet fibrinogen receptor, is required for normal hemostasis, we explored a potential role for SLP-76 in alpha IIb beta 3 signaling. Interaction of soluble or immobilized fibrinogen with normal human or murine platelets triggers rapid tyrosine phosphorylation of SLP-76. Moreover, platelet adhesion to fibrinogen stimulates actin rearrangements, filopodial and lamellipodial extension, and localization of tyrosine phosphorylated proteins to the cell periphery. In contrast, SLP-76-deficient murine platelets bind fibrinogen normally, but spread poorly and exhibit reduced levels of phosphotyrosine. The in vivo bleeding diathesis as well as the defects in platelet responses to fibrinogen and collagen are reversed by retroviral transduction of SLP-76 into bone marrow derived from SLP-76-deficient mice. These studies establish that SLP-76 functions downstream of alpha IIb beta 3 and collagen receptors in platelets. Furthermore, expression of SLP-76 in hematopoietic cells, including platelets, plays a necessary role in hemostasis.
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