ArticleProceedings of the National Academy of Sciences of the United States of America2000
Putting ion channels to work: mechanoelectrical transduction, adaptation, and amplification by hair cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed.
- Otolithic organs and vibratory sensitivity in frogs: do saccular otoconial volumes vary according to lifestyle?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Efferent control of hair cells mechanically coupled by artificial membranes.Scientific reports · 2025Article
- NOMPC ion channel hinge forms a gating spring that initiates mechanosensation.Nature neuroscience · 2025Article
- Hair Cell Regeneration: From Animals to Humans.Clinical and experimental otorhinolaryngology · 2024Review
- Toward the Bayesian brain: a generative model of information transmission by vestibular sensory neurons.Frontiers in neurology · 2024Article
- Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices.Science advances · 2022Article
- Fast adaptation of cooperative channels engenders Hopf bifurcations in auditory hair cells.Biophysical journal · 2022Article
- Cy3-ATP labeling of unfixed, permeabilized mouse hair cells.Scientific reports · 2021Article
- Article
- Mechanosensitive Regulation of Fibrosis.Cells · 2021Review
- Axonemal Dynein DNAH5 is Required for Sound Sensation in Drosophila Larvae.Neuroscience bulletin · 2021Article
- Origins of eukaryotic excitability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Kinetic Membrane Model of Outer Hair Cells.Biophysical journal · 2021Article
- Hair Cell Protection from Ototoxic Drugs.Neural plasticity · 2021Review
- Transient Receptor Potential (TRP) Channels in Head-and-Neck Squamous Cell Carcinomas: Diagnostic, Prognostic, and Therapeutic Potentials.International journal of molecular sciences · 2020Review
- Effects of Efferent Activity on Hair Bundle Mechanics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Diverse Mechanisms of Sound Frequency Discrimination in the Vertebrate Cochlea.Trends in neurosciences · 2020Review
- Effects of Moderate Static Magnetic Field on Neural Systems Is a Non-invasive Mechanical Stimulation of the Brain Possible Theoretically?Frontiers in neuroscience · 2020Article
- Active Biomechanics of Sensory Hair Bundles.Cold Spring Harbor perspectives in medicine · 2019Review
- Capacitive Bio-Inspired Flow Sensing Cupula.Sensors (Basel, Switzerland) · 2019Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
As in other excitable cells, the ion channels of sensory receptors produce electrical signals that constitute the cellular response to stimulation. In photoreceptors, olfactory neurons, and some gustatory receptors, these channels essentially report the results of antecedent events in a cascade of chemical reactions. The mechanoelectrical transduction channels of hair cells, by contrast, are coupled directly to the stimulus. As a consequence, the mechanical properties of these channels shape our hearing process from the outset of transduction. Channel gating introduces nonlinearities prominent enough to be measured and even heard. Channels provide a feedback signal that controls the transducer's adaptation to large stimuli. Finally, transduction channels participate in an amplificatory process that sensitizes and sharpens hearing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.