ArticleProceedings of the National Academy of Sciences of the United States of America2000
Molecular mechanisms of sound amplification in the mammalian cochlea.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Probing hair cell's mechano-transduction using two-tone suppression measurements.Scientific reports · 2019Article
- Review
- Myosin light-chain kinase is necessary for membrane homeostasis in cochlear inner hair cells.PloS one · 2012Article
- Dissecting the electromechanical coupling mechanism of the motor-protein prestin.Communicative & integrative biology · 2011Article
- Enhancement of sensitivity gain and frequency tuning by coupling of active hair bundles.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification.Brain research · 2008Article
- Sugar transport by mammalian members of the SLC26 superfamily of anion-bicarbonate exchangers.The Journal of physiology · 2003Article
- Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Reciprocal electromechanical properties of rat prestin: the motor molecule from rat outer hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- In vivo evidence for a cochlear amplifier in the hair-cell bundle of lizards.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mammalian hearing depends on the enhanced mechanical properties of the basilar membrane within the cochlear duct. The enhancement arises through the action of outer hair cells that act like force generators within the organ of Corti. Simple considerations show that underlying mechanism of somatic motility depends on local area changes within the lateral membrane of the cell. The molecular basis for this phenomenon is a dense array of particles that are inserted into the basolateral membrane and that are capable of sensing membrane potential field. We show here that outer hair cells selectively take up fructose, at rates high enough to suggest that a sugar transporter may be part of the motor complex. The relation of these findings to a recent candidate for the molecular motor is also discussed.
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