ArticleProceedings of the National Academy of Sciences of the United States of America2000
Two mechanisms for transducer adaptation in vertebrate hair cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 121 citations in OpenAlex.
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- Biomimetic Soft Polymer Microstructures and Piezoresistive Graphene MEMS Sensors Using Sacrificial Metal 3D Printing.ACS applied materials & interfaces · 2021Article
- Active Biomechanics of Sensory Hair Bundles.Cold Spring Harbor perspectives in medicine · 2019Review
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- An operating principle of the turtle utricle to detect wide dynamic range.Hearing research · 2018Article
- Mechanically Gated Ion Channels in Mammalian Hair Cells.Frontiers in cellular neuroscience · 2018Review
- Lipid bilayer mediates ion-channel cooperativity in a model of hair-cell mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The molecules that mediate sensory transduction in the mammalian inner ear.Current opinion in neurobiology · 2015Review
- Regulation of mechanosensation in C. elegans through ubiquitination of the MEC-4 mechanotransduction channel.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Frequency response properties of primary afferent neurons in the posterior lateral line system of larval zebrafish.Journal of neurophysiology · 2015Article
- Sensory hair cell death and regeneration in fishes.Frontiers in cellular neuroscience · 2015Review
- Mimicking the End Organ Architecture of Slowly Adapting Type I Afferents May Increase the Durability of Artificial Touch Sensors.IEEE Haptics Symposium : [proceedings]. IEEE Haptics Symposium · 2014Article
- Responses of cutaneous mechanoreceptors within fingerpad to stimulus information for tactile softness sensation of materials.Cognitive neurodynamics · 2013Article
- Mechanical overstimulation of hair bundles: suppression and recovery of active motility.PloS one · 2013Article
- Functional roles for myosin 1c in cellular signaling pathways.Cellular signalling · 2013Review
- Progress in cochlear physiology after Békésy.Hearing research · 2012Review
- Force sensor in simulated skin and neural model mimic tactile SAI afferent spiking response to ramp and hold stimuli.Journal of neuroengineering and rehabilitation · 2012Article
- Magnetic actuation of hair cells.Applied physics letters · 2011Article
- Intensity-invariant coding in the auditory system.Neuroscience and biobehavioral reviews · 2011Review
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Authors and funding
2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Deflection of the hair bundle atop a sensory hair cell modulates the open probability of mechanosensitive ion channels. In response to sustained deflections, hair cells adapt. Two fundamentally distinct models have been proposed to explain transducer adaptation. Both models support the notion that channel open probability is modulated by calcium that enters via the transduction channels. Both also suggest that the primary effect of adaptation is to shift the deflection-response [I(X)] relationship in the direction of the applied stimulus, thus maintaining hair bundle sensitivity. The models differ in several respects. They operate on different time scales: the faster on the order of a few milliseconds or less and the slower on the order of 10 ms or more. The model proposed to explain fast adaptation suggests that calcium enters and binds at or near the transduction channels to stabilize a closed conformation. The model proposed to explain the slower adaptation suggests that adaptation is mediated by an active, force-generating process that regulates the effective stimulus applied to the transduction channels. Here we discuss the evidence in support of each model and consider the possibility that both may function to varying degrees in hair cells of different species and sensory organs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.