ArticleProceedings of the National Academy of Sciences of the United States of America2000
Sequential repression and activation of the CCAAT enhancer-binding protein-alpha (C/EBPalpha ) gene during adipogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Noncoding variation near UBE2E2 orchestrates cardiometabolic pathophenotypes through polygenic effectors.JCI insight · 2024Article
- Vitamin A: A Key Inhibitor of Adipocyte Differentiation.PPAR research · 2023Review
- C/EBPα RegulatesInsects · 2022Article
- Epigenetic programming of Dnmt3a mediated by AP2α is required for granting preadipocyte the ability to differentiate.Cell death & disease · 2016Article
- Cooperation between HMGA1 and HIF-1 Contributes to Hypoxia-Induced VEGF and Visfatin Gene Expression in 3T3-L1 Adipocytes.Frontiers in endocrinology · 2016Article
- The role of C/EBP-α expression in human liver and liver fibrosis and its relationship with autophagy.International journal of clinical and experimental pathology · 2015Article
- Emerging roles of zinc finger proteins in regulating adipogenesis.Cellular and molecular life sciences : CMLS · 2013Review
- The BTB-containing protein Kctd15 is SUMOylated in vivo.PloS one · 2013Article
- Epimedium-derived flavonoids modulate the balance between osteogenic differentiation and adipogenic differentiation in bone marrow stromal cells of ovariectomized rats via Wnt/β-catenin signal pathway activation.Chinese journal of integrative medicine · 2012Article
- Article
- Activator protein 2 alpha (AP2alpha) suppresses 42 kDa C/CAAT enhancer binding protein alpha (p42(C/EBPalpha)) in head and neck squamous cell carcinoma.International journal of cancer · 2009Article
- Temporal profiling of the adipocyte proteome during differentiation using a five-plex SILAC based strategy.Journal of proteome research · 2009Article
- Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.Molecular and cellular biology · 2008Article
- Cited2 is required for fetal lung maturation.Developmental biology · 2008Article
- Review
- Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex.The EMBO journal · 2003Article
- A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription.Molecular and cellular biology · 2003Article
- Genistein inhibits CCAAT/enhancer-binding protein beta (C/EBPbeta) activity and 3T3-L1 adipogenesis by increasing C/EBP homologous protein expression.The Biochemical journal · 2002Article
- CCAAT/enhancer-binding proteins: structure, function and regulation.The Biochemical journal · 2002Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CCAAT enhancer-binding protein-alpha (C/EBPalpha) functions as a pleiotropic transcriptional activator of adipocyte genes during adipogenesis. Nuclear factor C/EBP undifferentiated protein (CUP), an isoform of activator protein-2alpha (AP-2alpha), binds to repressive elements in the C/EBPalpha gene promoter, silencing the gene until late in the differentiation program. The CUP regulatory element overlaps a Sp (GT-box) element in the promoter to which Sp3 (or Sp1) can bind. Binding by Sp3 or Sp1 and CUP/AP2-alpha is mutually exclusive. Sp3 is a strong transcriptional activator of the C/EBPalpha gene promoter in 3T3-L1 preadipocytes and Schneider cells, this activation being repressed by CUP/AP-2alpha. Sp3 is expressed throughout differentiation, whereas CUP/AP-2alpha, which is expressed only by preadipocytes, is down-regulated during differentiation coincident with transcription of the C/EBPalpha gene. Thus, CUP/AP-2alpha delays access of Sp3 to the Sp regulatory element, preventing premature expression of C/EBPalpha and thereby interference by C/EBPalpha (which is antimitotic) with mitotic clonal expansion, an essential early event in the differentiation program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.