ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
A cellular mechanism for the transformation of a sensory input into a motor command.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational Model.bioRxiv : the preprint server for biology · 2025Article
- Behavioral, Endocrine, and Neuronal Responses to Odors in Lampreys.Animals : an open access journal from MDPI · 2025Review
- Robust undulatory locomotion through neuromechanical adjustments in a dissipative medium.Journal of the Royal Society, Interface · 2025Article
- Ionic mechanisms underlying bistability in spinal motoneurons: insights from a computational model.Frontiers in cellular neuroscience · 2025Article
- Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks.Nature communications · 2023Article
- Brainstem neural mechanisms controlling locomotion with special reference to basal vertebrates.Frontiers in neural circuits · 2023Review
- Cholinergic Modulation of Locomotor Circuits in Vertebrates.International journal of molecular sciences · 2022Review
- Descending Dopaminergic Inputs to Reticulospinal Neurons Promote Locomotor Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A Brainstem Neural Substrate for Stopping Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- All-optical imaging and manipulation of whole-brain neuronal activities in behaving larval zebrafish.Biomedical optics express · 2018Article
- State-dependent sensorimotor gating in a rhythmic motor system.Journal of neurophysiology · 2017Article
- Supraspinal control of spinal reflex responses to body bending during different behaviours in lampreys.The Journal of physiology · 2017Article
- Differential Contribution of CaFrontiers in cellular neuroscience · 2017Article
- Dopamine and the Brainstem Locomotor Networks: From Lamprey to Human.Frontiers in neuroscience · 2017Review
- Convergent neuromodulation onto a network neuron can have divergent effects at the network level.Journal of computational neuroscience · 2016Article
- Sensory Activation of Command Cells for Locomotion and Modulatory Mechanisms: Lessons from Lampreys.Frontiers in neural circuits · 2016Review
- Facial Mechanosensory Influence on Forelimb Movement in Newborn Opossums, Monodelphis domestica.PloS one · 2016Article
- Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.Molecular biology of the cell · 2014Article
- Differences in the morphology of spinal V2a neurons reflect their recruitment order during swimming in larval zebrafish.The Journal of comparative neurology · 2014Article
- Functional motifs composed of morphologically homologous neurons repeated in the hindbrain segments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The initiation and control of locomotion largely depend on processing of sensory inputs. The cellular bases of locomotion have been extensively studied in lampreys where reticulospinal (RS) neurons constitute the main descending system activating and controlling the spinal locomotor networks. Ca(2+) imaging and intracellular recordings were used to study the pattern of activation of RS neurons in response to cutaneous stimulation. Pressure applied to the skin evoked a linear input/output relationship in RS neurons until a threshold level, at which a depolarizing plateau was induced, the occurrence of which was associated with the onset of swimming activity in a semi-intact preparation. The occurrence of a depolarizing plateau was abolished by blocking the NMDA receptors that are located on RS cells. Moreover, the depolarizing plateaus were accompanied by a rise in [Ca(2+)](i), and an intracellular injection of the Ca(2+) chelator BAPTA into single RS cells abolished the plateaus, suggesting that the latter are Ca(2+) dependent and rely on intrinsic properties of RS cells. The plateaus were shown to result from the activation of a Ca(2+)-activated nonselective cation current that maintains the cell in a depolarized state. It is concluded that this intrinsic property of the RS neuron is then responsible for the transformation of an incoming sensory signal into a motor command that is then forwarded to the spinal locomotor networks.
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11050140PMC6772722What OpenQuestion holds
Registered trials
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