ArticleJournal of virology2000
Thogoto virus matrix protein is encoded by a spliced mRNA.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- A novel accessory gene product of tick-borne Dhori-Orthomyxovirus, encoded by overlooked spliced transcripts of RNA segment 6.Journal of virology · 2025Article
- Identification of RNA Virus-Derived RdRp Sequences in Publicly Available Transcriptomic Data Sets.Molecular biology and evolution · 2023Article
- Comparative Study of Ten Thogotovirus Isolates and Their DistinctJournal of virology · 2022Article
- Multiple RNA virus matrix proteins interact with SLD5 to manipulate host cell cycle.The Journal of general virology · 2021Article
- Mx1 in Hematopoietic Cells Protects against Thogoto Virus Infection.Journal of virology · 2019Article
- Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.PLoS pathogens · 2018Article
- Role of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity.The Journal of biological chemistry · 2015Article
- Upolu virus and Aransas Bay virus, two presumptive bunyaviruses, are novel members of the family Orthomyxoviridae.Journal of virology · 2014Article
- Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influenza A virus.The Journal of biological chemistry · 2014Article
- Genomic and antigenic characterization of Jos virus.The Journal of general virology · 2012Article
- The interferon antagonist ML protein of thogoto virus targets general transcription factor IIB.Journal of virology · 2008Article
- Novel gene product of Thogoto virus segment 6 codes for an interferon antagonist.Journal of virology · 2003Article
- Rescue of recombinant Thogoto virus from cloned cDNA.Journal of virology · 2001Article
- Interferon, Mx, and viral countermeasures.Cytokine & growth factor reviewsReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thogoto virus (THOV) is a tick-transmitted orthomyxovirus with a segmented, negative-stranded RNA genome. In this study, we investigated the coding strategy of RNA segment 6 and found that it contains 956 nucleotides and codes for the matrix (M) protein. The full-length cDNA contains a single, long reading frame that lacks a stop codon but has coding capacity for a putative 35-kDa protein. In contrast, the M protein of THOV has an apparent molecular mass of 29 kDa as assessed by polyacrylamide gel electrophoresis. Therefore, we investigated the possibility of posttranscriptional processing of segment 6 transcripts by reverse transcription-PCR and identified a spliced mRNA that contains a stop codon and is translated into the 29-kDa M protein. Interestingly, the nontemplated UGA stop codon is generated by the splicing event itself. Thus, the unusual M coding strategy of THOV resembles that of Influenza C virus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.