ArticleOncogene2000
Interferon-beta induces S phase slowing via up-regulated expression of PML in squamous carcinoma cells.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells.Cell reports · 2022Article
- Estrogen receptor β ligation inhibits Hodgkin lymphoma growth by inducing autophagy.Oncotarget · 2017Article
- Interaction between the human papillomavirus 16 E7 oncoprotein and gelsolin ignites cancer cell motility and invasiveness.Oncotarget · 2016Article
- MicroRNA-196a promotes cervical cancer proliferation through the regulation of FOXO1 and p27Kip1.British journal of cancer · 2014Article
- PML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation of MMP2.Cell cycle (Georgetown, Tex.) · 2014Article
- Type I interferons induce apoptosis by balancing cFLIP and caspase-8 independent of death ligands.Molecular and cellular biology · 2013Article
- Early transcriptional pattern of angiogenesis induced by EGCG treatment in cervical tumour cells.Journal of cellular and molecular medicine · 2012Article
- Article
- Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).The Journal of biological chemistry · 2011Article
- Receptor density is key to the alpha2/beta interferon differential activities.Molecular and cellular biology · 2009Article
- PML: An emerging tumor suppressor and a target with therapeutic potential.Cancer therapy · 2009Article
- Targeting promyelocytic leukemia protein: a means to regulating PML nuclear bodies.International journal of biological sciences · 2009Review
- TRAIL is a key target in S-phase slowing-dependent apoptosis induced by interferon-beta in cervical carcinoma cells.Oncogene · 2005Article
- Characterization of gene expression induced by RET with MEN2A or MEN2B mutation.The American journal of pathology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type I Interferon (IFN) and all-trans retinoic acid (RA) inhibit cell proliferation of squamous carcinoma cell lines (SCC). Examinations of growth-affected cell populations show that SCC lines ME-180 and SiHa treated with IFN-beta undergo a specific slower progression through the S phase that seems to trigger cellular death. In combination treatment RA potentiates IFN-beta effect in SCC ME-180 but not in SiHa cell line, partially resistant to RA antiproliferative action. RA added as single agent affects cell proliferation differently by inducing a slight G1 accumulation. The IFN-beta-induced S phase lengthening parallels the increased expression of PML, a nuclear phosphoprotein specifically up-regulated at transcriptional level by IFN, whose overexpression induces cell growth inhibition and tumor suppression. We report that PML up-regulation may account for the alteration of cell cycle progression induced by IFN-beta in SCC by infecting cells with PML-PINCO recombinant retrovirus carrying the PML-3 cDNA under the control of the 5' LTR. In fact PML overexpression reproduces the IFN-beta-induced S phase lengthening. These findings provide important insight into the mechanism of tumor suppressing function of PML and could allow PML to be included in the pathways responsible for IFN-induced cell growth suppression.
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Registered trials
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