ArticleOncogene2000
Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 60 citations in OpenAlex.
- The French Cohort of DNA Repair-Deficient Xeroderma Pigmentosum Patients: Risk of Hematological Malignancies.Cancers · 2023Article
- Xeroderma Pigmentosum Complementation Group C (XPC): Emerging Roles in Non-Dermatologic Malignancies.Frontiers in oncology · 2022Review
- XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature.Nature communications · 2020Article
- A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer.Cancer discovery · 2016Article
- Premature skin aging features rescued by inhibition of NADPH oxidase activity in XPC-deficient mice.The Journal of investigative dermatology · 2015Article
- XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species.Biochimica et biophysica acta · 2011Article
- XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas.The Journal of clinical investigation · 2011Article
- Stimulation of DNA Glycosylase Activities by XPC Protein Complex: Roles of Protein-Protein Interactions.Journal of nucleic acids · 2010Article
- Caloric restriction and genomic stability.Nucleic acids research · 2007Review
- New functions of XPC in the protection of human skin cells from oxidative damage.The EMBO journal · 2006Article
- Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Tumor-prone phenotype of the DDB2-deficient mice.Oncogene · 2005Article
- Article
- Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase.The EMBO journal · 2003Article
- A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions.Oncogene · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA damages caused by cellular metabolites and environmental agents induce mutations, that may predispose to cancer. Nucleotide excision repair (NER) is a major cellular defence mechanism acting on a variety of DNA lesions. Here, we show that spontaneous mutant frequencies at the Hprt gene increased 30-fold in T-lymphocytes of 1 year old Xpc-/- mice, possessing only functional transcription-coupled repair (TCR). Hprt mutant frequencies in Xpa-/- and Csb-/- mice that both have a defect in this NER subpathway, remained low during ageing. In contrast to current models, the elevated mutation rate in Xpc-/- mice does not lead to an increased tumour incidence or premature ageing. Oncogene (2000) 19, 5034 - 5037
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