Evidence map›Paper›PMID 11042657›Full record

ArticleBone marrow transplantation2000

Treatment and outcome of invasive Aspergillus infections in allogeneic BMT recipients.

E Jantunen, P Ruutu, A Piilonen, L Volin, T Parkkali, T Ruutu

Abstract read
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Aspergillus fumigatus and related species.Cold Spring Harbor perspectives in medicine · 2014
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

E JantunenDepartment of Medicine, Helsinki University Central Hospital, Finland.
P Ruutu
A Piilonen
L Volin
T Parkkali
T Ruutu
Helsinki University Hospital · FIInstitute for Molecular Medicine Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The outcome of invasive aspergillosis (IA) has been considered poor in allogeneic BMT recipients. We analyzed retrospectively the treatment and outcome of IA diagnosed during life in a recent cohort of 20 allogeneic BMT recipients. All patients were initially treated with amphotericin B (AmB) (conventional 16, liposomal 4). Due to toxicity, conventional AmB was changed to a liposomal preparation in 10 patients. Five patients also received itraconazole and three underwent surgery. Of 19 evaluable patients, two patients achieved a complete response and a partial response was observed in five patients (response rate 37%). The median survival was 37 days after the diagnosis. Only two patients (10%) were cured. The prognosis of allogeneic BMT recipients with IA has remained poor. Although treatment responses are common, immunosuppression aggravated by GVHD and its treatment, as well as the commonly disseminated presentation of IA, seem to be major obstacles to the success of therapy. Bone Marrow Transplantation (2000) 26, 759-762.

Indexed as

AdolescentAdrenal Cortex HormonesAdultAmphotericin BAntifungal AgentsAspergillosisAutopsyBone Marrow TransplantationCohort StudiesFemaleHumansLung Diseases, FungalMaleMiddle AgedNeutropeniaRetrospective StudiesAdrenal Cortex HormonesAmphotericin BAntifungal Agents

Identifiers

PMID11042657
OpenAlexW2068438157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.