ArticleGenome research2000
SNP profile within the human major histocompatibility complex reveals an extreme and interrupted level of nucleotide diversity.
Article in Genome research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 107 citations in OpenAlex.
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- Characterization and genetic diversity of MHC class II DRB genes in the Arabian camel (Camelus dromedarius).Immunogenetics · 2023Article
- Intronic primers reveal unexpectedly high major histocompatibility complex diversity in Antarctic fur seals.Scientific reports · 2022Article
- Using de novo genome assembly and high-throughput sequencing to characterize the MHC region in a non-model bird, the Eurasian coot.Scientific reports · 2022Article
- SNP-Density Crossover Maps of Polymorphic Transposable Elements and HLA Genes Within MHC Class I Haplotype Blocks and Junction.Frontiers in genetics · 2020Article
- TheAnimals : an open access journal from MDPI · 2019Article
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- Consumption, contact and copulation: how pathogens have shaped human psychological adaptations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Lack of evidence for selection favouring MHC haplotypes that combine high functional diversity.Heredity · 2018Article
- Association of SNP variants of MHC Class II DRB gene with thermo-physiological traits in tropical goats.Tropical animal health and production · 2017Article
- MHC class II β exon 2 variation in pardalotes (Pardalotidae) is shaped by selection, recombination and gene conversion.Immunogenetics · 2017Article
- The opossum MHC genomic region revisited.Immunogenetics · 2015Article
- Introgression from domestic goat generated variation at the major histocompatibility complex of Alpine ibex.PLoS genetics · 2014Article
- Evolution by selection, recombination, and gene duplication in MHC class I genes of two Rhacophoridae species.BMC evolutionary biology · 2013Article
- Molecular characterization of sexual diversity in a population of Serpula lacrymans, a tetrapolar basidiomycete.G3 (Bethesda, Md.) · 2013Article
- MHC class I of saltwater crocodiles (Crocodylus porosus): polymorphism and balancing selection.Immunogenetics · 2012Article
- Ancestral polymorphism at the major histocompatibility complex (MHCIIß) in the Nesospiza bunting species complex and its sister species (Rowettia goughensis).BMC evolutionary biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human major histocompatibility complex (MHC) is characterized by polymorphic multicopy gene families, such as HLA and MIC (PERB11); duplications; insertions and deletions (indels); and uneven rates of recombination. Polymorphisms at the antigen recognition sites of the HLA class I and II genes and at associated neutral sites have been attributed to balancing selection and a hitchhiking effect, respectively. We, and others, have previously shown that nucleotide diversity between MHC haplotypes at non-HLA sites is unusually high (>10%) and up to several times greater than elsewhere in the genome (0.08%-0.2%). We report here the most extensive analysis of nucleotide diversity within a continuous sequence in the genome. We constructed a single nucleotide polymorphism (SNP) profile that reveals a pattern of extreme but interrupted levels of nucleotide diversity by comparing a continuous sequence within haplotypes in three genomic subregions of the MHC. A comparison of several haplotypes within one of the genomic subregions containing the HLA-B and -C loci suggests that positive selection is operating over the whole subgenomic region, including HLA and non-HLA genes. [The sequence data for the multiple haplotype comparisons within the class I region have been submitted to DDBJ/EMBL/GenBank under accession nos. AF029061, AF029062, and AB031005-AB031010. Additional sequence data have been submitted to the DDBJ data library under accession nos. AB031005-AB03101 and AF029061-AF029062.]
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.