ArticleThe Biochemical journal2000
Shared control of hepatic glycogen synthesis by glycogen synthase and glucokinase.
Article in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Duration of morning hyperinsulinemia determines hepatic glucose uptake and glycogen storage later in the day.American journal of physiology. Endocrinology and metabolism · 2024Article
- Duration of Morning Hyperinsulinemia Determines Hepatic Glucose Uptake and Glycogen Storage Later in the Day.bioRxiv : the preprint server for biology · 2024Article
- Article
- Metabolic control analysis of hepatic glycogen synthesis in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Regulation of hepatic glucose metabolism in health and disease.Nature reviews. Endocrinology · 2017Review
- Glucose autoregulation is the dominant component of the hormone-independent counterregulatory response to hypoglycemia in the conscious dog.American journal of physiology. Endocrinology and metabolism · 2017Article
- Article
- Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter.Molecular and cellular biology · 2013Article
- Molecular and functional characterization of glycogen synthase in the porcine satellite cells under insulin treatment.Molecular and cellular biochemistry · 2012Article
- Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats.Diabetologia · 2011Article
- Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs.The Journal of pharmacology and experimental therapeutics · 2011Article
- Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis.The Journal of biological chemistry · 2010Article
- A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin.American journal of physiology. Endocrinology and metabolism · 2009Article
- Molecular physiology of mammalian glucokinase.Cellular and molecular life sciences : CMLS · 2009Review
- Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance.Diabetologia · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used recombinant adenoviruses (AdCMV-RLGS and AdCMV-GK) to overexpress the liver isoforms of glycogen synthase (GS) and glucokinase (GK) in primary cultured rat hepatocytes. Glucose activated overexpressed GS in a dose-dependent manner and caused the accumulation of larger amounts of glycogen in the AdCMV-RLGS-treated hepatocytes. The concentration of intermediate metabolites of the glycogenic pathway, such as glucose 6-phosphate (Glc-6-P) and UDP-glucose, were not significantly altered. GK overexpression also conferred on the hepatocyte an enhanced capacity to synthesize glycogen in response to glucose, as described previously [Seoane, Gómez-Foix, O'Doherty, Gómez-Ara, Newgard and Guinovart (1996) J. Biol. Chem. 271, 23756-23760], although, in this case, they accumulated Glc-6-P. When GS and GK were simultaneously overexpressed, the accumulation of glycogen was enhanced in comparison with cells overexpressing either GS or GK. Our results are consistent with the hypothesis that liver GS catalyses the rate-limiting step of hepatic glycogen synthesis. However, hepatic glycogen deposition from glucose is submitted to a system of shared control in which the 'controller', GS, is, in turn, controlled by GK. This control is indirectly exerted through Glc-6-P, which 'switches on' GS dephosphorylation and activation.
Indexed as
Identifiers
11042138PMC1221423W2113512217What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.