ArticleThe Biochemical journal2000
Different receptors use inositol trisphosphate to mobilize Ca(2+) from different intracellular pools.
Article in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Endogenous signalling pathways and caged IPJournal of cell science · 2017Article
- Cyclic AMP Recruits a Discrete Intracellular CaCell reports · 2017Article
- IP3 receptors: Take four IP3 to open.Science signaling · 2016Article
- Cyclic AMP directs inositol (1,4,5)-trisphosphate-evoked Ca2+ signalling to different intracellular Ca2+ stores.Journal of cell science · 2013Article
- How does intracellular Ca2+ oscillate: by chance or by the clock?Biophysical journal · 2008Article
- Inositol trisphosphate analogues selective for types I and II inositol trisphosphate receptors exert differential effects on vasopressin-stimulated Ca2+ inflow and Ca2+ release from intracellular stores in rat hepatocytes.The Biochemical journal · 2004Article
- Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+.The Biochemical journal · 2003Review
- GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity.The EMBO journal · 2003Article
- Parathyroid hormone increases the sensitivity of inositol trisphosphate receptors by a mechanism that is independent of cyclic AMP.British journal of pharmacology · 2003Article
- Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cells expressing different receptors linked to Ins(1,4,5)P(3) formation, maximal stimulation of any one of them often releases all the Ins(1,4,5)P(3)-sensitive Ca(2+) stores, suggesting that Ins(1,4, 5)P(3) is used similarly by many receptors. In single HEK-293 cells, ATP and carbamylcholine (CCh) stimulated Ca(2+) release from intracellular stores via a pathway that was entirely dependent on Ins(1,4,5)P(3). After stimulation with maximal concentrations of ATP or CCh in Ca(2+)-free medium, there was no response to a second stimulation with the same agonist, indicating that each agonist had emptied the Ins(1,4,5)P(3)-sensitive stores to which it had access. However, the Ca(2+) release evoked by the second agonist was unaffected by prior stimulation with the first. We conclude that Ins(1,4,5)P(3) mediates the effects of both receptors, but Ins(1,4, 5)P(3) is more versatile than hitherto supposed, because the spatial organization of the signalling pathways apparently allows Ins(1,4, 5)P(3) made in response to each agonist to interact with different Ins(1,4,5)P(3) receptors.
Indexed as
Identifiers
11042123PMC1221408W1965151570What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.