ArticleThe Plant cell2000
Cell cycle regulation of the tobacco ribonucleotide reductase small subunit gene is mediated by E2F-like elements.
Article in The Plant cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 104 citations in OpenAlex.
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- Genome-wide characterization of DNA methyltransferase family genes implies GhDMT6 improving tolerance of salt and drought on cotton.BMC plant biology · 2024Article
- Arabidopsis Target of Rapamycin Coordinates With Transcriptional and Epigenetic Machinery to Regulate Thermotolerance.Frontiers in plant science · 2021Article
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- Deep Sequencing of the Medicago truncatula Root Transcriptome Reveals a Massive and Early Interaction between Nodulation Factor and Ethylene Signals.Plant physiology · 2015Article
- Timing of the G1/S transition in tobacco pollen vegetative cells as a primary step towards androgenesis in vitro.Plant cell reports · 2014Article
- Evolutionary developmental transcriptomics reveals a gene network module regulating interspecific diversity in plant leaf shape.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition.Frontiers in biology · 2014Article
- Genome-wide annotation, expression profiling, and protein interaction studies of the core cell-cycle genes in Phalaenopsis aphrodite.Plant molecular biology · 2014Article
- p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc.Plant physiology · 2011Article
- A novel E2F-like protein involved in transcriptional activation of cyst wall protein genes in Giardia lamblia.The Journal of biological chemistry · 2011Article
- Identification and characterization of alternative promoters, transcripts and protein isoforms of zebrafish R2 gene.PloS one · 2011Article
- SHORT-ROOT and SCARECROW regulate leaf growth in Arabidopsis by stimulating S-phase progression of the cell cycle.Plant physiology · 2010Article
- Seed storage protein gene promoters contain conserved DNA motifs in Brassicaceae, Fabaceae and Poaceae.BMC plant biology · 2009Article
- Ribonucleotide reductase regulation in response to genotoxic stress in Arabidopsis.Plant physiology · 2009Article
- Preferential up-regulation of G2/M phase-specific genes by overexpression of the hyperactive form of NtmybA2 lacking its negative regulation domain in tobacco BY-2 cells.Plant physiology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ribonucleotide reductase (RNR) is a key enzyme involved in the DNA synthesis pathway. The RNR-encoded genes are cell cycle regulated and specifically expressed in S phase. The promoter of the RNR2 gene encoding for the small subunit was isolated from tobacco. Both in vivo and in vitro studies of the DNA-protein interactions in synchronized BY2 tobacco cells showed that two E2F-like motifs were involved in multiple specific complexes, some of which displayed cell cycle-regulated binding activities. Moreover, these two elements could specifically interact with a purified tobacco E2F protein. Involvement of the E2F elements in regulating the RNR2 promoter was checked by functional analyses in synchronized transgenic BY2 cells transformed with various RNR2 promoter constructs fused to the luciferase reporter gene. The two E2F elements were involved in upregulation of the promoter at the G1/S transition and mutation of both elements prevented any significant induction of the RNR promoter. In addition, one of the E2F elements sharing homology with the animal E2F/cell cycle-dependent element motif behaved like a repressor when outside of the S phase. These data provide evidence that E2F elements play a crucial role in cell cycle regulation of gene transcription in plants.
Indexed as
Identifiers
11041892PMC149135W2170113350What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.