ArticleThe Plant cell2000
HRT gene function requires interaction between a NAC protein and viral capsid protein to confer resistance to turnip crinkle virus.
Article in The Plant cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed, 260 citations in OpenAlex.
- Structural, evolutionary and functional insights into the NAC gene family in Stevia rebaudiana and identification of important genes regulating steviol glycosides biosynthesis.BMC plant biology · 2026Article
- Isolation and Expression Pattern Analysis ofPlants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification of NAC Family Genes and Their Expression Analyses in Response to Osmotic Stress inInternational journal of molecular sciences · 2024Article
- P4 protein of an Indian isolate of rice tungro bacilliform virus modulates gene silencing.Virus genes · 2024Article
- The Role of Plant Transcription Factors in the Fight against Plant Viruses.International journal of molecular sciences · 2023Review
- Article
- Comprehensive analysis of pathogen-responsive wheat NAC transcription factors: new candidates for crop improvement.G3 (Bethesda, Md.) · 2022Article
- Roles of RNA silencing in viral and non-viral plant immunity and in the crosstalk between disease resistance systems.Nature reviews. Molecular cell biology · 2022Review
- The membrane associated NAC transcription factors ANAC060 and ANAC040 are functionally redundant in the inhibition of seed dormancy in Arabidopsis thaliana.Journal of experimental botany · 2022Article
- The NAC transcription factor ANAC017 regulates aluminum tolerance by regulating the cell wall-modifying genes.Plant physiology · 2022Article
- Genome-Wide Identification and Analysis of the NAC Transcription Factor Gene Family in Garden Asparagus (Genes · 2022Article
- NbNAC42 and NbZFP3 Transcription Factors Regulate the Virus InducibleFrontiers in plant science · 2022Article
- Engineering Resistance Against Viruses in Field Crops Using CRISPR- Cas9.Current genomics · 2021Review
- The miR164-GhCUC2-GhBRC1 module regulates plant architecture through abscisic acid in cotton.Plant biotechnology journal · 2021Article
- Review
- Gene Expression Analysis of InducedInternational journal of molecular sciences · 2021Article
- Microarray analysis ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- p24Viruses · 2020Article
- Genome-wide analysis of the NAC transcription factor family in broomcorn millet (Panicum miliaceum L.) and expression analysis under drought stress.BMC genomics · 2020Article
- Article
31 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An Arabidopsis protein was found to interact specifically with the capsid protein (CP) of turnip crinkle virus (TCV) through yeast two-hybrid screening. This protein, designated TIP (for TCV-interacting protein), was found to be a member of the recently recognized NAC family of proteins. NAC proteins have been implicated in the regulation of development of plant embryos and flowers. TIP alone was able to activate expression of reporter genes in yeast if fused to a DNA binding domain, suggesting that it may be a transcriptional activator. The TIP binding region in the TCV CP has been mapped to the N-terminal 25 amino acids. Site-directed mutagenesis within this region revealed that loss of the TIP-CP interaction in the yeast two-hybrid assay correlated with loss of the ability of TCV to induce the hypersensitive response and resistance in the TCV-resistant Arabidopsis ecotype Dijon (Di-0 and its inbred line Di-17). These data suggest that TIP is an essential component in the TCV resistance response pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.