ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2000
Longitudinal evaluation of CD4+ and CD8+ peripheral blood and mammary gland lymphocytes in cows experimentally inoculated with Staphylococcus aureus.
Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Low Neutrophil Counts in Milk Are Associated with an Increased Frequency of Antimicrobial Treatments.Pathogens (Basel, Switzerland) · 2025Article
- Using High-Resolution Differential Cell Counts (HRDCCs) in Bovine Milk and Blood to Monitor the Immune Status over the Entire Lactation Period.Animals : an open access journal from MDPI · 2022Article
- Adaptive Cell-Mediated Immunity in the Mammary Gland of Dairy Ruminants.Frontiers in veterinary science · 2022Review
- Milk lymphocyte profile and macrophage functions: new insights into the immunity of the mammary gland in quarters infected with Corynebacterium bovis.BMC veterinary research · 2021Article
- Polymorphism of Selected Regions ofAnimals : an open access journal from MDPI · 2020Article
- Inverted CD4Veterinary immunology and immunopathology · 2020Article
- Effect of intramammary infusion of recombinant bovine GM-CSF and IL-8 on CMT score, somatic cell count, and milk mononuclear cell populations in Holstein cows with Staphylococcus aureus subclinical mastitis.Veterinary research communications · 2017Article
- Whole-genome regulation analysis of histone H3 lysin 27 trimethylation in subclinical mastitis cows infected by Staphylococcus aureus.BMC genomics · 2016Article
- The T Cell Response to Staphylococcus aureus.Pathogens (Basel, Switzerland) · 2016Article
- Article
- Genome-wide bovine H3K27me3 modifications and the regulatory effects on genes expressions in peripheral blood lymphocytes.PloS one · 2012Article
- Multifactorial relationships between intramammary invasion by Staphylococcus aureus and bovine leukocyte markers.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2007Article
- Blood and milk cellular immune responses of mastitic non-periparturient cows inoculated with Staphylococcus aureus.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus is a major pathogen associated with mastitis, a disease affecting both women and dairy cows. The longitudinal profiles of bovine peripheral blood and mammary gland lymphocyte phenotypes in response to S. aureus-induced mastitis were investigated in dairy cows. Increased percentage of CD4 lymphocytes in the mammary gland between 1 and 8 days post-inoculation, increased milk CD4 protein density per cell between 1-8 days post-inoculation, and a statistically significant negative correlation between post-inoculation bacterial counts in milk and blood lymphocyte CD4 protein density were found. Together with blood and milk leukocyte counts, the milk lymphocyte CD4/CD8 ratio and the milk lymphocyte CD4 protein density were more informative indicators than milk somatic cell counts and bacteriology for identification of early vs. late inflammatory phases. These findings suggest that CD4+ lymphocytes play a protective role in the early stages of S. aureus-induced mastitis.
Indexed as
Identifiers
11041502PMC1189624W73718846What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.