ArticleThe Journal of cell biology2000
Targeted ablation of the murine involucrin gene.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 86 citations in OpenAlex.
- C. elegans epicuticlins define specific compartments in the apical extracellular matrix and function in wound repair.Development (Cambridge, England) · 2024Article
- Involucrin Modulates Vitamin D Receptor Activity in the Epidermis.The Journal of investigative dermatology · 2023Article
- ZFP750 affects the cutaneous barrier through regulating lipid metabolism.Science advances · 2023Article
- MAB21L4 regulates the TGF-β-induced expression of target genes in epidermal keratinocytes.Journal of biochemistry · 2022Article
- Article
- Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa.Nature communications · 2021Article
- Loricrin: Past, Present, and Future.International journal of molecular sciences · 2020Review
- SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation.The Journal of clinical investigation · 2020Article
- Recent evolution of the human skin barrier.Experimental dermatology · 2018Review
- Corneocyte proteomics: Applications to skin biology and dermatology.Experimental dermatology · 2018Review
- The Molecular Revolution in Cutaneous Biology: EDC and Locus Control.The Journal of investigative dermatology · 2017Review
- Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility.eLife · 2014Article
- Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero.Developmental cell · 2012Article
- Expression of structural proteins in human female and male genital epithelia and implications for sexually transmitted infections.Biology of reproduction · 2012Article
- Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier.PloS one · 2012Article
- Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis.Nature reviews. Molecular cell biology · 2011Review
- Control of gene expression by the retinoic acid-related orphan receptor alpha in HepG2 human hepatoma cells.PloS one · 2011Article
- Ancient origin of the gene encoding involucrin, a precursor of the cross-linked envelope of epidermis and related epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentas.PloS one · 2008Article
- Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.The Journal of cell biology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Involucrin is synthesized in abundance during terminal differentiation of keratinocytes. Involucrin is a substrate for transglutaminase and one of the precursors of the cross-linked envelopes present in the corneocytes of the epidermis and other stratified squamous epithelia. These envelopes make an important contribution to the physical resistance of the epidermis. We have generated mice lacking involucrin from embryonic stem cells whose involucrin gene had been ablated by homologous recombination. These mice developed normally, possessed apparently normal epidermis and hair follicles, and made cornified envelopes that could not be distinguished from those of wild-type mice. No compensatory increase of mRNA for other envelope precursors was observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.