ArticleLancet (London, England)2000
First permanent implant of the Jarvik 2000 Heart.
Article in Lancet (London, England), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Recent Developments in Ventricular Assist Device Therapy.Reviews in cardiovascular medicine · 2025Review
- Evolution of a circulatory support system with full implantability: personal perspectives on a long journey.The British journal of cardiology · 2022Article
- Long-term continuous-flow left ventricular assist devices (LVAD) as bridge to heart transplantation.Journal of thoracic disease · 2015Article
- Inappropriate use of neurally adjusted ventilator assist.BMJ case reports · 2012Article
- The use of computational fluid dynamics in the development of ventricular assist devices.Medical engineering & physics · 2011Review
- Hematologic effects of continuous flow left ventricular assist devices.Journal of cardiovascular translational research · 2010Article
- Thirty-five years of mechanical circulatory support at the Texas Heart Institute: an updated overview.Texas Heart Institute journal · 2005Article
- First Turkish experience with the MicroMed DeBakey VAD.Texas Heart Institute journal · 2003Article
- Mechanical circulatory support: expanding knowledge and experience in a challenging patient subset.Intensive care medicine · 2001Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeart failure is a major public-health concern. Quality and duration of life on maximum medical therapy are poor. The availability of donor hearts is severely limited, therefore an alternative approach is necessary. We have explored the use of a new type of left-ventricular assist device intended as a long-term solution to end-stage heart failure.
methodsAs part of a prospective clinical trial, we implanted the first permanent Jarvik 2000 Heart--an intraventricular device with an innovative power delivery system--into a 61-year-old man (New York Heart Association functional class IV) with dilated cardiomyopathy. We assessed the effect of this left-ventricular assist device on both native heart function and the symptoms and systemic characteristics of heart failure.
findingsThe Jarvik 2000 Heart sustained the patient's circulation, and was practical and user-friendly. After 6 weeks, exercise tolerance, myocardial function, and end-organ function improved. Symptoms of heart failure have resolved, and continuous decreased pulse-pressure perfusion has had no adverse effects in the short term. There has been no significant haemolysis and no device-related complications. The skull-mounted pedestal is unobtrusive and has healed well.
conclusionsThe initial success of this procedure raises the possibility of a new treatment for end-stage heart failure. In the longer term, its role will be determined by mechanical reliability.
Indexed as
Identifiers
11036895What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.