Evidence map›Paper›PMID 11035768›Full record

ArticleInfection and immunity2000

Latency-associated peptide of transforming growth factor beta enhances mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice.

K A Wilkinson, T D Martin, S M Reba, H Aung, R W Redline, W H Boom, Z Toossi, S A Fulton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Dual Inhibition ofJournal of medicinal chemistry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

K A WilkinsonDivision of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984, USA.
T D Martin
S M Reba
H Aung
R W Redline
W H Boom
Z Toossi
S A Fulton
Office of Infectious Diseases · USUniversity Hospitals of Cleveland · US

Funding

MYCOBACTERIUM TUBERCULOSIS INFECTION IN THE LUNGR01HL055967 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI BOOM, W. HENRY · 1995 to 2010
$4.2M
IMMUNOSUPPRESSION IN MYCOBACTERIAL DISEASESR01AI018471 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI TOOSSI, ZAHRA · 1987 to 2001
$545k
IMMUNOSUPPRESSION IN MYCOBACTERIAL DISEASESR22AI018471 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ELLNER, JERROLD J. · 1985 to 1985
–
NHLBI NIH HHS HL-55967NHLBI NIH HHS R01 HL055967NIAID NIH HHS AI-18471
6 · The paper itself

Abstract

Latency-associated peptide of transforming growth factor beta (TGF-beta) (LAP) was used to determine whether in vivo modulation of TGF-beta bioactivity enhanced pulmonary immunity to Mycobacterium bovis BCG infection in C57BL/6 mice. LAP decreased BCG growth in the lung and enhanced antigen-specific T-cell proliferation and gamma interferon mRNA expression. Thus, susceptibility of the lung to primary BCG infection may be partially mediated by the immunosuppressive effects of TGF-beta.

Indexed as

AnimalsFemaleInterferon-gammaLungLymphocyte ActivationMiceMice, Inbred C57BLMycobacterium bovisRNA, MessengerT-LymphocytesTransforming Growth Factor betaTuberculosisInterferon-gammaRNA, MessengerTransforming Growth Factor beta

Identifiers

PMID11035768
PMCPMC97742
OpenAlexW2097092620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.