ArticleInfection and immunity2000
Essential role of platelet-activating factor in control of Leishmania (Leishmania) amazonensis infection.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Integration of hepatic lipidomics and transcriptomics reveals dysregulation of lipid metabolism in a golden hamster model of visceral leishmaniasis.Frontiers in immunology · 2025Article
- Data Independent Acquisition Reveals In-Depth Serum Proteome Changes in Canine Leishmaniosis.Metabolites · 2023Article
- Concentrations of PGEPathogens (Basel, Switzerland) · 2022Article
- Platelet-Activating Factor as an Effector for Environmental Stressors.Handbook of experimental pharmacology · 2020Article
- Dissecting the Mechanism of IntracellularFrontiers in microbiology · 2020Article
- Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4.PLoS pathogens · 2019Article
- 6,7-Dehydroroyleanone diterpene derived from Tetradenia riparia essential oil modulates IL-4/IL-12 release by macrophages that are infected with Leishmania amazonensis.Parasitology research · 2019Article
- Expression and Activity of COX-1 and COX-2 in Acanthamoeba sp.-Infected Lungs According to the Host Immunological Status.International journal of molecular sciences · 2018Article
- Photodynamic Therapy for the Treatment of American Tegumentary Leishmaniasis: Evaluation of Therapies Association in Experimentally Infected Mice WithJournal of lasers in medical sciences · 2018Article
- In Vitro and In Vivo Control of Secondary Bacterial Infection Caused by Leishmania major.International journal of environmental research and public health · 2017Article
- The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control.Purinergic signalling · 2017Article
- Cross-resistance of Leishmania infantum isolates to nitric oxide from patients refractory to antimony treatment, and greater tolerance to antileishmanial responses by macrophages.Parasitology research · 2016Article
- Antileishmanial activity of the essential oil from Tetradenia riparia obtained in different seasons.Memorias do Instituto Oswaldo Cruz · 2015Article
- Evaluation of α,β-unsaturated ketones as antileishmanial agents.Antimicrobial agents and chemotherapy · 2015Article
- Th1-biased immunomodulation and therapeutic potential of Artemisia annua in murine visceral leishmaniasis.PLoS neglected tropical diseases · 2015Article
- Detection of driver metabolites in the human liver metabolic network using structural controllability analysis.BMC systems biology · 2014Article
- Leishmania parasites possess a platelet-activating factor acetylhydrolase important for virulence.Molecular and biochemical parasitology · 2012Article
- Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages.PloS one · 2010Article
- Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis.Immunology · 2008Article
- Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves.Parasitology research · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study we investigated the role of platelet-activating factor (PAF) and prostaglandins in experimental Leishmania (Leishmania) amazonensis infection and the relationship between these mediators and nitric oxide (NO) production. Mouse peritoneal macrophages elicited with thioglicolate were infected with leishmania amastigotes, and the infection index determined 48 h later. The course of infection was monitored for 5 weeks in mice infected in the footpad with promastigotes by measuring the footpad swelling and parasite load in regional lymph nodes and spleen. The addition of PAF to C57BL/6 mouse macrophages significantly inhibited parasite growth and induced NO production. Treatment of macrophages with a selective PAF antagonist, WEB2086, increased the infection, indicating that endogenously produced PAF regulates macrophage ability to control leishmania infection. This effect of PAF was abolished by addition of the inhibitor of NO synthesis, L-NAME, to the cultures. The addition of prostaglandin E(2) significantly increased the infection and NO production. Treatment with cyclo-oxygenase inhibitor, indomethacin, reduced the infection and PAF-induced release of NO. Thus, the increased NO production induced by PAF seems to be mediated by prostaglandins. The more-selective inhibitors of cyclo-oxygenase 2, nimesulide and NS-398, had no significant effect. Thus, antileishmanial activity correlates better with the presence of PAF or absence of prostaglandins than with NO production. In vivo treatment with PAF antagonists significantly increased leishmania lesions, as well as the parasite load, in regional lymph nodes and spleens. These findings indicate that PAF is essential for the control of leishmania infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.