ArticleInfection and immunity2000
Genetic dissection of primary and secondary responses to a widespread natural pathogen of the gut, Eimeria vermiformis.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Toltrazuril and diclazuril: comparative evaluation of anti-coccidial drugs using a murine model.The Journal of veterinary medical science · 2022Article
- Coccidiosis: Recent Progress in Host Immunity and Alternatives to Antibiotic Strategies.Vaccines · 2022Review
- Coupling between tolerance and resistance for two relatedEcology and evolution · 2020Article
- Dissecting the Genomic Architecture of Resistance toFrontiers in genetics · 2018Article
- Dual RNA-seq reveals no plastic transcriptional response of the coccidian parasite Eimeria falciformis to host immune defenses.BMC genomics · 2017Article
- A Novel Vaccine Delivery Model of the ApicomplexanFrontiers in immunology · 2017Article
- Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva.International journal for parasitology · 2016Article
- Population, genetic, and antigenic diversity of the apicomplexan Eimeria tenella and their relevance to vaccine development.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Suitable in vitro culture of Eimeria bovis meront II stages in bovine colonic epithelial cells and parasite-induced upregulation of CXCL10 and GM-CSF gene transcription.Parasitology research · 2015Article
- γδ T cells play a protective role during infection with Nippostrongylus brasiliensis by promoting goblet cell function in the small intestine.Immunology · 2011Article
- T cell reactions of Eimeria bovis primary and challenge-infected calves.Parasitology research · 2010Article
- Suppression of airway inflammation by a natural acute infection of the intestinal epithelium.Mucosal immunology · 2009Article
- Porcine isosporosis: infection dynamics, pathophysiology and immunology of experimental infections.Wiener klinische Wochenschrift · 2007Review
- Intestinal intraepithelial lymphocytes sustain the epithelial barrier function against Eimeria vermiformis infection.Infection and immunity · 2006Article
- Treatment of mice with the anticoccidial drug Toltrazuril does not interfere with the development of a specific cellular intestinal immune response to Eimeria falciformis.Parasitology research · 2005Article
- Ponazuril inhibits the development of Eimeria vermiformis in experimentally infected outbred Swiss mice.Parasitology research · 2005Article
- The influence of follicular migration on T-cell differentiation.Immunology · 2004Review
- Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite.The Journal of experimental medicine · 2003Article
- Antigenic diversity in Eimeria maxima and the influence of host genetics and immunization schedule on cross-protective immunity.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Because most pathogens initially challenge the body at epithelial surfaces, it is important to dissect the mechanisms that underlie T-cell responses to infected epithelial cells in vivo. The coccidian parasites of the genus Eimeria are protozoan gut pathogens that elicit a potent, protective immune response in a wide range of host species. CD4+ alpha beta T cells and gamma interferon (IFN-gamma) are centrally implicated in the primary immunoprotective response. To define any additional requirements for the primary response and to develop a comparison between the primary and the secondary response, we have studied Eimeria infections of a broad range of genetically altered mice. We find that a full-strength primary response depends on beta(2)-microglobulin (class I major histocompatibility complex [MHC] and class II MHC and on IFN-gamma and interleukin-6 (IL-6) but not on TAP1, perforin, IL-4, Fas ligand, or inducible nitric oxide synthetase. Indeed, MHC class II-deficient and IFN-gamma-deficient mice are as susceptible to primary infection as mice deficient in all alpha beta T cells. Strikingly, the requirements for a highly effective alpha beta-T-cell-driven memory response are less stringent, requiring neither IFN-gamma nor IL-6 nor class I MHC. The class II MHC dependence was also reduced, with adoptively transferable immunity developing in MHC class II(-/-) mice. Besides the improved depiction of an immune response to a natural gut pathogen, the finding that effective memory can be elicited in the absence of primary effector responses appears to create latitude in the design of vaccine strategies.
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