ArticleInfection and immunity2000
Genetic diversity of the capsular polysaccharide C biosynthesis region of Bacteroides fragilis.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
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- Gut SymbiontmBio · 2017Article
- An antimicrobial protein of the gut symbiont Bacteroides fragilis with a MACPF domain of host immune proteins.Molecular microbiology · 2014Article
- A refined palate: bacterial consumption of host glycans in the gut.Glycobiology · 2013Review
- Characterization of adherent bacteroidales from intestinal biopsies of children and young adults with inflammatory bowel disease.PloS one · 2013Article
- A family of transcriptional antitermination factors necessary for synthesis of the capsular polysaccharides of Bacteroides fragilis.Journal of bacteriology · 2009Article
- A general O-glycosylation system important to the physiology of a major human intestinal symbiont.Cell · 2009Article
- Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases.Cell host & microbe · 2008Review
- Evolution of symbiotic bacteria in the distal human intestine.PLoS biology · 2007Article
- Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Mpi recombinase globally modulates the surface architecture of a human commensal bacterium.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Polysaccharide biosynthesis locus required for virulence of Bacteroides fragilis.Infection and immunity · 2001Article
- Immunochemical and biological characterization of three capsular polysaccharides from a single Bacteroides fragilis strain.Infection and immunity · 2001Article
- Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci.Infection and immunity · 2000Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
A genetic approach was used to assess the heterogeneity of the capsular polysaccharide C (PS C) biosynthesis locus of Bacteroides fragilis and to determine whether distinct loci contain genes whose products are likely to be involved in conferring charged groups that enable the B. fragilis capsular polysaccharides to induce abscesses. A collection of 50 B. fragilis strains was examined. PCR analysis demonstrated that the genes flanking the PS C biosynthesis region are conserved, whereas the genes within the loci are heterogeneous. Only cfiA(+) B. fragilis strains, which represent 3% of the clinical isolates of B. fragilis, displayed heterogeneity in the regions flanking the polysaccharide biosynthesis genes. Primers were designed in the conserved regions upstream and downstream of the PS C locus and were used to amplify the region from 45 of the 50 B. fragilis strains studied. Fourteen PS C genetic loci could be differentiated by a combination of PCR and extended PCR. These loci ranged in size from 14 to 26 kb. Hybridization analysis with genes from the PS C loci of strains 9343 and 638R revealed that the majority of strains contain homologs of wcgC (N-acetylmannosamine dehydrogenase), wcfF (putative dehydrogenase), and wcgP (putative aminotransferase). The data suggest that the synthesis of polysaccharides that have zwitterionic characteristics rendering them able to induce abscesses is common in B. fragilis.
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