ArticleInfection and immunity2000
Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Advances in bacterial synthesis pathways of bioflocculants and their applications in mine wastewater treatment.World journal of microbiology & biotechnology · 2026Review
- In vitro assessment of the impact of astragalus, pineapple stem and bergamot extracts on human fecal bacteria.BMC complementary medicine and therapies · 2026Article
- The Ambivalent Nature ofToxins · 2025Review
- Convergent and divergent biosynthetic strategies towards phosphonic acid natural products.Current opinion in chemical biology · 2022Review
- In Silico Study of Cell Surface Structures ofInternational journal of molecular sciences · 2022Article
- Phosphonate production by marine microbes: Exploring new sources and potential function.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The gastrointestinal pathogen Campylobacter jejuni metabolizes sugars with potential help from commensal Bacteroides vulgatus.Communications biology · 2020Article
- Rapid analysis of metagenomic data using signature-based clustering.BMC bioinformatics · 2018Article
- Gut microbiota utilize immunoglobulin A for mucosal colonization.Science (New York, N.Y.) · 2018Article
- Purification and characterization of phosphonoglycans from Glycomyces sp. strain NRRL B-16210 and Stackebrandtia nassauensis NRRL B-16338.Journal of bacteriology · 2014Article
- Article
- Efficient electrotransformation of Bacteroides fragilis.Applied and environmental microbiology · 2010Article
- The modulation of adaptive immune responses by bacterial zwitterionic polysaccharides.International journal of microbiology · 2010Article
- A family of transcriptional antitermination factors necessary for synthesis of the capsular polysaccharides of Bacteroides fragilis.Journal of bacteriology · 2009Article
- Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.Infection and immunity · 2009Article
- Biosynthesis of phosphonic and phosphinic acid natural products.Annual review of biochemistry · 2009Review
- Niche-specific features of the intestinal bacteroidales.Journal of bacteriology · 2008Article
- Bacteroides: the good, the bad, and the nitty-gritty.Clinical microbiology reviews · 2007Review
- Phase-variable expression of a family of glycoproteins imparts a dynamic surface to a symbiont in its human intestinal ecosystem.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Synergy in polymicrobial infections in a mouse model of type 2 diabetes.Infection and immunity · 2005Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Bacteroides fragilis produces a capsular polysaccharide complex (CPC) that is directly involved in its ability to induce abscesses. Two distinct capsular polysaccharides, polysaccharide A (PS A) and PS B, have been shown to be synthesized by the prototype strain for the study of abscesses, NCTC9343. Both of these polysaccharides in purified form induce abscesses in animal models. In this study, we demonstrate that the CPC of NCTC9343 is composed of at least three distinct capsular polysaccharides: PS A, PS B, and PS C. A previously described locus contains genes whose products are involved in the biosynthesis of PS C rather than PS B as was originally suggested. The actual PS B biosynthesis locus was cloned, sequenced, and found to contain 22 genes in an operon-type structure. A mutant with a large chromosomal deletion of the PS B biosynthesis locus was created so that the contribution of PS B to the formation of abscesses could be assessed in a rodent model. Although purified PS B can induce abscesses, removal of this polysaccharide does not attenuate the organism's ability to induce abscesses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.