ArticleAmerican journal of human genetics2000
A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia.Scientific reports · 2013Pooled it
- Heterogeneity-based genome search meta-analysis for preeclampsia.Human genetics · 2006Pooled it
- The role of epigenetics in women's reproductive health: the impact of environmental factors.Frontiers in endocrinology · 2024Review
- Genetic variation in placental insufficiency: What have we learned over time?Frontiers in cell and developmental biology · 2022Review
- Genetic Variations in Metallothionein Genes and Susceptibility to Hypertensive Disorders of Pregnancy: A Case-Control Study.Frontiers in genetics · 2022Article
- Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study.BJOG : an international journal of obstetrics and gynaecology · 2021Article
- Distinct placental molecular processes associated with early-onset and late-onset preeclampsia.Theranostics · 2021Article
- Preeclampsia-Associated lncRNAMolecular therapy. Nucleic acids · 2020Article
- Exploring the Molecular Aetiology of Preeclampsia by Massive Parallel Sequencing of DNA.Current hypertension reports · 2020Review
- Non-additive effects of ACVR2A in preeclampsia in a Philippine population.BMC pregnancy and childbirth · 2019Article
- Analysis of the Epigenome in Multiplex Pre-eclampsia Families IdentifiesFrontiers in genetics · 2019Article
- Candidate Gene, Genome-Wide Association and Bioinformatic Studies in Pre-eclampsia: a Review.Current hypertension reports · 2018Review
- Preeclampsia and Related Cardiovascular Risk: Common Genetic Background.Current hypertension reports · 2018Review
- Genetic predisposition to preeclampsia is conferred by fetal DNA variants near FLT1, a gene involved in the regulation of angiogenesis.American journal of obstetrics and gynecology · 2018Review
- The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia.Journal of hypertension · 2017Article
- Article
- Coverage, compliance, acceptability and feasibility of a program to prevent pre-eclampsia and eclampsia through calcium supplementation for pregnant women: an operations research study in one district of Nepal.BMC pregnancy and childbirth · 2016Article
- Exome sequencing in pooled DNA samples to identify maternal pre-eclampsia risk variants.Scientific reports · 2016Article
- The Norwegian preeclampsia family cohort study: a new resource for investigating genetic aspects and heritability of preeclampsia and related phenotypes.BMC pregnancy and childbirth · 2015Article
- Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort.Journal of hypertension · 2015Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have shown that genetic factors contribute to the etiology of the common and serious pregnancy-specific disorder pre-eclampsia (PE)/eclampsia (E). Candidate-gene studies have provided evidence (albeit controversial) of linkage to several genes, including angiotensinogen on 1q42-43 and eNOS on 7q36. A recent medium-density genome scan in Icelandic families identified significant linkage to D2S286 (at 94.05 cM) on chromosome 2p12 and suggestive linkage to D2S321 (at 157.5 cM) on chromosome 2q23. In the present article, the authors report the results of a medium-density genome scan in 34 families, representing 121 affected women, from Australia and New Zealand. Multipoint nonparametric linkage analysis, using the GENEHUNTER-PLUS program, showed suggestive evidence of linkage to chromosome 2 (LOD=2.58), at 144.7 cM, between D2S112 and D2S151, and to chromosome 11q23-24, between D11S925 and D11S4151 (LOD=2.02 at 121.3 cM). Given the limited precision of estimates of the map location of disease-predisposing loci for complex traits, the present finding on chromosome 2 is consistent with the finding from the Icelandic study, and it may represent evidence of the same locus segregating in the population from Australia and New Zealand. The authors propose that the PE/E-linked locus on chromosome 2p should be designated the "PREG1" (pre-eclampsia, eclampsia gene 1) locus.
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