ArticleThe Journal of experimental medicine2000
Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 93 citations in OpenAlex.
- Depletion of CD8αβVaccines · 2020Article
- Cross-Presenting XCR1Cells · 2020Review
- Pulmonary Dendritic Cell Subsets Shape the Respiratory Syncytial Virus-Specific CD8+ T Cell Immunodominance Hierarchy in Neonates.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response.PLoS pathogens · 2010Article
- Dendritic cell cross-priming is essential for immune responses to Listeria monocytogenes.PloS one · 2009Article
- The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Geography and plumbing control the T cell response to infection.Immunology and cell biology · 2008Review
- An epigenetic vaccine model active in the prevention and treatment of melanoma.Journal of translational medicine · 2007Article
- Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells.Infection and immunity · 2007Article
- Cross-priming of cytotoxic T cells dictates antigen requisites for modified vaccinia virus Ankara vector vaccines.Journal of virology · 2007Article
- Steady state dendritic cells present parenchymal self-antigen and contribute to, but are not essential for, tolerization of naive and Th1 effector CD4 cells.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection.Virology · 2007Article
- CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2005Article
- Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection.The Journal of experimental medicine · 2005Article
- Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo.The Journal of experimental medicine · 2002Article
- Salmonella enterica serovar Typhi live vector vaccines delivered intranasally elicit regional and systemic specific CD8+ major histocompatibility class I-restricted cytotoxic T lymphocytes.Infection and immunity · 2002Article
- In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.Immunity · 2002Article
- Strategies for designing and optimizing new generation vaccines.Nature reviews. Immunology · 2001Review
- Cross-presentation in viral immunity and self-tolerance.Nature reviews. Immunology · 2001Review
- CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.The Journal of experimental medicine · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow (BM)-derived antigen-presenting cells (APCs) are potent stimulators of T cell immune responses. We investigated the requirements for antigen presentation by these cells in priming cytotoxic T lymphocyte (CTL) responses to intracellular bacterial and viral pathogens. [Parent-->F(1)] radiation BM chimeras were constructed using C57BL/6 donors and (C57BL/6 x BALB/c)F(1) recipients. Infection of chimeric mice with either Listeria monocytogenes or vaccinia virus expressing the nucleoprotein (NP) antigen from lymphocytic choriomeningitis virus (LCMV) primed H2-D(b)-restricted, but not H2-K(d)-restricted CTL responses, demonstrating the requirement for BM-derived APCs for successful priming of CTL responses to these pathogens. Surprisingly, this did not hold true for chimeric mice infected with LCMV itself. LCMV-infected animals developed strong CTL responses specific for both H2-D(b)- and H2-L(d)-restricted NP epitopes. These findings indicate that in vivo priming of CTL responses to LCMV is remarkably insensitive to deficiencies in antigen presentation by professional BM-derived APCs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.