ArticleAmerican journal of human genetics2000
Linkage disequilibrium analysis of biallelic DNA markers, human quantitative trait loci, and threshold-defined case and control subjects.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.PLoS genetics · 2012Pooled it
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- Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders.Biological psychiatry · 2011Pooled it
- Dopamine genes and nicotine dependence in treatment-seeking and community smokers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Trial
- Extreme sampling design in genetic association mapping of quantitative trait loci using balanced and unbalanced case-control samples.Scientific reports · 2019Article
- Variation in PTCHD2, CRISP3, NAP1L4, FSCB, and AP3B2 associated with spherical equivalent.Molecular vision · 2016Article
- Deep sequencing of RYR3 gene identifies rare and common variants associated with increased carotid intima-media thickness (cIMT) in HIV-infected individuals.Journal of human genetics · 2015Article
- Cumulative risk on the oxytocin receptor gene (OXTR) underpins empathic communication difficulties at the first stages of romantic love.Social cognitive and affective neuroscience · 2014Article
- Genetic implication of a novel thiamine transporter in human hypertension.Journal of the American College of Cardiology · 2014Article
- Hypnotizability and Catechol-O-Methyltransferase (COMT) polymorphysms in Italians.Frontiers in human neuroscience · 2014Article
- Genetic association between RGS1 and internalizing disorders.Psychiatric genetics · 2013Article
- Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses.Journal of the American College of Cardiology · 2012Article
- Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure.Journal of hypertension · 2012Article
- Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension.Current hypertension reports · 2011Article
- Statistical analysis strategies for association studies involving rare variants.Nature reviews. Genetics · 2010Review
- Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study.PLoS genetics · 2010Article
- Genome-wide case/control studies in hypertension: only the 'tip of the iceberg'.Journal of hypertension · 2010Article
- Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension.Journal of the American College of Cardiology · 2010Article
- Extremes of unexplained variation as a phenotype: an efficient approach for genome-wide association studies of cardiovascular disease.Circulation. Cardiovascular genetics · 2010Article
- Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.Human molecular genetics · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Linkage disequilibrium (LD) mapping has been applied to many simple, monogenic, overtly Mendelian human traits, with great success. However, extensions and applications of LD mapping approaches to more complex human quantitative traits have not been straightforward. In this article, we consider the analysis of biallelic DNA marker loci and human quantitative trait loci in settings that involve sampling individuals from opposite ends of the trait distribution. The purpose of this sampling strategy is to enrich samples for individuals likely to possess (and not possess) trait-influencing alleles. Simple statistical models for detecting LD between a trait-influencing allele and neighboring marker alleles are derived that make use of this sampling scheme. The power of the proposed method is investigated analytically for some hypothetical gene-effect scenarios. Our studies indicate that LD mapping of loci influencing human quantitative trait variation should be possible in certain settings. Finally, we consider possible extensions of the proposed methods, as well as areas for further consideration and improvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.