ArticleMolecular psychiatry2000
A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit hyperactivity disorder.
Article in Molecular psychiatry, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Role of dopamine receptors in ADHD: a systematic meta-analysis.Molecular neurobiology · 2012Pooled it
- ADHD and the DRD4 exon III 7-repeat polymorphism: an international meta-analysis.Social cognitive and affective neuroscience · 2010Pooled it
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- ADHD and reification: Four ways a psychiatric construct is portrayed as a disease.Frontiers in psychiatry · 2022Article
- Genetic associations between ADHD and dopaminergic genes (DAT1 and DRD4) VNTRs in Korean children.Genes & genomics · 2018Article
- Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder.Neurochemistry international · 2014Review
- No Association between the Response to Methylphenidate and DRD4 Gene Polymorphism in Korean Attention Deficit Hyperactivity Disorder: A Case Control Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2013Article
- Is there a role for rare variants in DRD4 gene in the susceptibility for ADHD? Searching for an effect of allelic heterogeneity.Molecular psychiatry · 2012Article
- Why most biomedical findings echoed by newspapers turn out to be false: the case of attention deficit hyperactivity disorder.PloS one · 2012Article
- Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder.European child & adolescent psychiatry · 2009Article
- Molecular genetics of monoamine transporters: relevance to brain disorders.Neurochemical research · 2008Review
- A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.Molecular and cellular neurosciences · 2007Article
- The Italian preadolescent mental health project (PrISMA): rationale and methods.International journal of methods in psychiatric research · 2006Article
- No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study.BMC medical genetics · 2005Article
- Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample.Molecular psychiatry · 2005Article
- Rationale for psychostimulants in ADHD.BMJ (Clinical research ed.) · 2005Article
- Attention deficit hyperactivity disorder: fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11.American journal of human genetics · 2004Article
- No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study.BMC psychiatry · 2004Article
- Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) gene as a positional candidate for attention-deficit/hyperactivity disorder in the 16p13 region.Molecular psychiatry · 2004Article
- Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD.Molecular psychiatry · 2004Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Attention deficit hyperactivity disorder (ADHD) is a highly heritable psychiatric condition of early childhood onset characterised by marked inattention, hyperactivity and impulsiveness. Molecular genetic investigations of ADHD have found positive associations with the 480-bp allele of a VNTR situated in the 3' untranslated region of DAT1 and allele 7 of a VNTR in exon 3 of DRD4. A number of independent studies have attempted to replicate these findings but the results have been inconsistent. We used both family-based and case control approaches to examine these polymorphisms in a sample of 137 children diagnosed with ICD-10, DSM-IV or DSM-III-R ADHD. We found no evidence of association with the DAT1 polymorphism, despite a sample size that has up to 80% power to detect a previously reported effect size. We observed a significant increase in the DRD4 7 repeat allele amongst ADHD probands (21.7%) and their parents (18.9% in mothers, 22.3% in fathers), compared to ethnically matched controls (12.8%). However TDT analysis showed no preferential transmission of allele 7 to ADHD probands.
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