ArticleJournal of muscle research and cell motility2000
A thermodynamic muscle model and a chemical basis for A.V. Hill's muscle equation.
Article in Journal of muscle research and cell motility, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Scaling in Biological Systems: A Molecular-Ensemble Duality.bioRxiv : the preprint server for biology · 2025Article
- Stochastic force generation in an isometric binary mechanical system.The Journal of general physiology · 2024Article
- Four phases of a force transient emerge from a binary mechanical system.Journal of muscle research and cell motility · 2024Article
- Mixed-scale versus multiscale models of muscle contraction.Biophysical journal · 2024Article
- The Problem with Inventing Molecular Mechanisms to Fit Thermodynamic Equations of Muscle.International journal of molecular sciences · 2023Article
- Cells solved the Gibbs paradox by learning to contain entropic forces.Scientific reports · 2023Article
- Article
- Thermodynamics and Kinetics of a Binary Mechanical System: Mechanisms of Muscle Contraction.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- A chemical thermodynamic model of motor enzymes unifies chemical-Fx and powerstroke models.Biophysical journal · 2022Article
- Heart failure drug changes the mechanoenzymology of the cardiac myosin powerstroke.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Hill's equation of muscle performance and its hidden insight on molecular mechanisms.The Journal of general physiology · 2013Review
- From cycling between coupled reactions to the cross-bridge cycle: mechanical power output as an integral part of energy metabolism.Metabolites · 2012Article
- The energetics of allosteric regulation of ADP release from myosin heads.Physical chemistry chemical physics : PCCP · 2009Article
- Site-directed spectroscopic probes of actomyosin structural dynamics.Annual review of biophysics · 2009Review
- The biochemical kinetics underlying actin movement generated by one and many skeletal muscle myosin molecules.Biophysical journal · 2002Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
Direct measurements of a relationship between force and actin-myosin biochemistry in muscle suggest that molecular forces in active muscle rapidly equilibrate among. not within, individual myosin crossbridges [Baker et al. (1999) Biophys J 77: 2657 2664]. This observation suggests a thermodynamic model of muscle contraction in which muscle, not an individual myosin crossbridge, is treated as a near-equilibrium system. The general approach can be applied to any ensemble of molecular motors that undergo a physicochemical step against a constant external potential. In this paper we apply the model to a simple two-state crossbridge scheme like that proposed by A.F. Huxley (1957) [Prog Biophys 7: 255 317], and we immediately obtain A.V. Hill's muscle equation. We show that this equation accurately describes steady-state muscle mechanics, biochemistry and energetics. This thermodynamic model provides a novel description of force-dependent actin-myosin kinetics in muscle and provides precise chemical expressions for myosin cooperativity, myosinduty ratios, the number of working strokes per ATP hydrolyzed, muscle efficiency. and energy transfer.
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