ArticleJournal of bacteriology2000
Acquisition of the rfb-gnd cluster in evolution of Escherichia coli O55 and O157.
Article in Journal of bacteriology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- Genomic and stress resistance characterization ofMicrobiology spectrum · 2025Article
- Cellular function of the GndA microprotein during heat shock.bioRxiv : the preprint server for biology · 2025Article
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- Temperate Bacteriophages-The Powerful Indirect Modulators of Eukaryotic Cells and Immune Functions.Viruses · 2021Review
- Genome evolution and the emergence of pathogenicity in avian Escherichia coli.Nature communications · 2021Article
- Culture independent analysis using gnd as a target gene to assess Escherichia coli diversity and community structure.Scientific reports · 2017Article
- Evidence for Contemporary Switching of the O-Antigen Gene Cluster between Shiga Toxin-ProducingFrontiers in microbiology · 2017Article
- A combinational approach of multilocus sequence typing and other molecular typing methods in unravelling the epidemiology of Erysipelothrix rhusiopathiae strains from poultry and mammals.Veterinary research · 2015Article
- Article
- Association of clustered regularly interspaced short palindromic repeat (CRISPR) elements with specific serotypes and virulence potential of shiga toxin-producing Escherichia coli.Applied and environmental microbiology · 2014Article
- Phylogenetic analysis of non-O157 Shiga toxin-producing Escherichia coli strains by whole-genome sequencing.Journal of clinical microbiology · 2012Article
- Phylogeny of Shiga toxin-producing Escherichia coli O157 isolated from cattle and clinically ill humans.Molecular biology and evolution · 2012Article
- Article
- Enterohemorrhagic Escherichia coli O157:H7 gene expression profiling in response to growth in the presence of host epithelia.PloS one · 2009Article
- Genome evolution in major Escherichia coli O157:H7 lineages.BMC genomics · 2007Article
- Sequence-based typing of genetic targets encoded outside of the O-antigen gene cluster is indicative of Shiga toxin-producing Escherichia coli serogroup lineages.Journal of medical microbiology · 2007Article
- Expression of putative virulence factors of Escherichia coli O157:H7 differs in bovine and human infections.Infection and immunity · 2006Article
- Competitive metagenomic DNA hybridization identifies host-specific microbial genetic markers in cow fecal samples.Applied and environmental microbiology · 2006Article
- Development of PCR assays targeting genes in O-antigen gene clusters for detection and identification of Escherichia coli O45 and O55 serogroups.Applied and environmental microbiology · 2005Article
- Multilocus sequence typing versus pulsed-field gel electrophoresis for characterization of extended-spectrum beta-lactamase-producing Escherichia coli isolates.Journal of clinical microbiology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The rfb region specifies the structure of lipopolysaccharide side chains that comprise the diverse gram-negative bacterial somatic (O) antigens. The rfb locus is adjacent to gnd, which is a polymorphic gene encoding 6-phosphogluconate dehydrogenase. To determine if rfb and gnd cotransfer, we sequenced gnd in five O55 and 13 O157 strains of Escherichia coli. E. coli O157:H7 has a gnd allele (allele A) that is only 82% identical to the gnd allele (allele D) of closely related E. coli O55:H7. In contrast, gnd alleles of E. coli O55 in distant lineages are >99.9% identical to gnd allele D. Though gnd alleles B and C in E. coli O157 that are distantly related to E. coli O157:H7 are more similar to allele A than to allele D, there are nucleotide differences at 4 to 6% of their sites. Alleles B and C can be found in E. coli O157 in different lineages, but we have found allele A only in E. coli O157 belonging to the DEC5 lineage. DNA 3' to the O55 gnd allele in diverse E. coli lineages has sequences homologous to tnpA of the Salmonella enterica serovar Typhimurium IS200 element, E. coli Rhs elements (including an H-rpt gene), and portions of the O111 and O157 rfb regions. We conclude that rfb and gnd cotransferred into E. coli O55 and O157 in widely separated lineages and that recombination was responsible for recent antigenic shifts in the emergence of pathogenic E. coli O55 and O157.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.