ArticleAmerican journal of physiology. Cell physiology2000
Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle.
Article in American journal of physiology. Cell physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- JAK inhibition with tofacitinib rapidly increases contractile force in human skeletal muscle.Life science alliance · 2024Trial
- Transcriptome Profiling of Etridiazole-Exposed Zebrafish (International journal of molecular sciences · 2023Article
- Effects of β‑hydroxybutyric acid and ghrelin on the motility and inflammation of gastric antral smooth muscle cells involving the regulation of growth hormone secretagogue receptor.Molecular medicine reports · 2019Article
- Genetics of Thoracic and Abdominal Aortic Diseases.Circulation research · 2019Review
- Article
- HeterozygousFrontiers in physiology · 2019Article
- Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives.European biophysics journal : EBJ · 2016Review
- Pyruvate Dehydrogenase Phosphatase Regulatory Gene Expression Correlates with Exercise Training Insulin Sensitivity Changes.Medicine and science in sports and exercise · 2016Article
- Regulation of pulmonary endothelial barrier function by kinases.American journal of physiology. Lung cellular and molecular physiology · 2016Review
- Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.Cardiovascular research · 2016Article
- Regulation of 130-kDa smooth muscle myosin light chain kinase expression by an intronic CArG element.The Journal of biological chemistry · 2013Article
- Smooth muscle myosin light chain kinase efficiently phosphorylates serine 15 of cardiac myosin regulatory light chain.Biochemical and biophysical research communications · 2011Article
- MLCK-independent phosphorylation of MLC20 and its regulation by MAP kinase pathway in human bladder smooth muscle cells.Cytoskeleton (Hoboken, N.J.) · 2011Article
- Effects of a myosin light chain kinase inhibitor on the optics and accommodation of the avian crystalline lens.Molecular vision · 2011Article
- Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive.American journal of physiology. Heart and circulatory physiology · 2010Article
- Mlck1a is expressed in zebrafish thrombocytes and is an essential component of thrombus formation.Journal of thrombosis and haemostasis : JTH · 2010Article
- Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase.PloS one · 2009Article
- Characterization of tightly associated smooth muscle myosin-myosin light-chain kinase-calmodulin complexes.Journal of molecular biology · 2009Article
- Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice.Gastroenterology · 2008Article
- Myosin regulatory light chain phosphorylation attenuates cardiac hypertrophy.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The purpose of this study was to characterize myosin light chain kinase (MLCK) expression in cardiac and skeletal muscle. The only classic MLCK detected in cardiac tissue, purified cardiac myocytes, and in a cardiac myocyte cell line (AT1) was identical to the 130-kDa smooth muscle MLCK (smMLCK). A complex pattern of MLCK expression was observed during differentiation of skeletal muscle in which the 220-kDa-long or "nonmuscle" form of MLCK is expressed in undifferentiated myoblasts. Subsequently, during myoblast differentiation, expression of the 220-kDa MLCK declines and expression of this form is replaced by the 130-kDa smMLCK and a skeletal muscle-specific isoform, skMLCK in adult skeletal muscle. These results demonstrate that the skMLCK is the only tissue-specific MLCK, being expressed in adult skeletal muscle but not in cardiac, smooth, or nonmuscle tissues. In contrast, the 130-kDa smMLCK is ubiquitous in all adult tissues, including skeletal and cardiac muscle, demonstrating that, although the 130-kDa smMLCK is expressed at highest levels in smooth muscle tissues, it is not a smooth muscle-specific protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.