ArticleMolecular biology of the cell2000
Expression of multiple UNC-13 proteins in the Caenorhabditis elegans nervous system.
Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 86 citations in OpenAlex.
- Article
- ImmatureProceedings of the National Academy of Sciences of the United States of America · 2026Article
- ImmaturebioRxiv : the preprint server for biology · 2025Article
- Regulated microexon alternative splicing in single neurons tunes synaptic function.EMBO reports · 2025Article
- Aberrant Positions of the Chemosensory Neurons in the Neurotransmitter-Release MutantInternational journal of molecular sciences · 2024Article
- Low-dose naltrexone extends healthspan and lifespan iniScience · 2024Article
- Expression and function of Caenorhabditis elegans UNCP-18, a paralog of the SM protein UNC-18.Genetics · 2023Article
- Muscle-directed mechanosensory feedback activates egg-laying circuit activity and behavior in Caenorhabditis elegans.Current biology : CB · 2023Article
- Article
- Article
- Functional Roles of UNC-13/Munc13 and UNC-18/Munc18 in Neurotransmission.Advances in neurobiology · 2023Review
- Robust regulatory architecture of pan-neuronal gene expression.Current biology : CB · 2022Article
- Article
- A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- AlternativeFrontiers in immunology · 2020Article
- Ferritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans.Redox biology · 2020Article
- Intrinsic and extrinsic mechanisms of synapse formation and specificity in C. elegans.Cellular and molecular life sciences : CMLS · 2019Review
- Gene Cascade Finder: A tool for identification of gene cascades and its application in Caenorhabditis elegans.PloS one · 2019Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The Caenorhabditis elegans UNC-13 protein and its mammalian homologues are important for normal neurotransmitter release. We have identified a set of transcripts from the unc-13 locus in C. elegans resulting from alternative splicing and apparent alternative promoters. These transcripts encode proteins that are identical in their C-terminal regions but that vary in their N-terminal regions. The most abundant protein form is localized to most or all synapses. We have analyzed the sequence alterations, immunostaining patterns, and behavioral phenotypes of 31 independent unc-13 alleles. Many of these mutations are transcript-specific; their phenotypes suggest that the different UNC-13 forms have different cellular functions. We have also isolated a deletion allele that is predicted to disrupt all UNC-13 protein products; animals homozygous for this null allele are able to complete embryogenesis and hatch, but they die as paralyzed first-stage larvae. Transgenic expression of the entire gene rescues the behavior of mutants fully; transgenic overexpression of one of the transcripts can partially compensate for the genetic loss of another. This finding suggests some degree of functional overlap of the different protein products.
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