ArticlePlant physiology2000
The Arabidopsis UVH1 gene is a homolog of the yeast repair endonuclease RAD1.
Article in Plant physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 70 citations in OpenAlex.
- Plant tolerance mechanisms to DNA-damaging UV stress.Journal of experimental botany · 2025Review
- Role of the nucleotide excision repair endonuclease XPF in the kinetoplastid parasite Trypanosoma brucei.Scientific reports · 2025Article
- CRISPR/Cas-based precision genome editing via microhomology-mediated end joining.Plant biotechnology journal · 2021Review
- The Dark Side of UV-Induced DNA Lesion Repair.Genes · 2020Review
- DNA- and DNA-Protein-Crosslink Repair in Plants.International journal of molecular sciences · 2019Review
- The XPF-ERCC1 Complex Is Essential for Genome Stability and Is Involved in the Mechanism of Gene Targeting inFrontiers in plant science · 2019Article
- Repair of adjacent single-strand breaks is often accompanied by the formation of tandem sequence duplications in plant genomes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Genome-Wide Analysis Indicates Lineage-Specific Gene Loss during Papilionoideae Evolution.Genome biology and evolution · 2016Article
- Arabidopsis DNA polymerase lambda mutant is mildly sensitive to DNA double strand breaks but defective in integration of a transgene.Frontiers in plant science · 2015Article
- The regulation of UV-B responses by the circadian clock.Plant signaling & behavior · 2015Article
- Preparation of efficient excision repair competent cell-free extracts from C. reinhardtii cells.PloS one · 2014Article
- Poly(ADP-ribose)polymerases are involved in microhomology mediated back-up non-homologous end joining in Arabidopsis thaliana.Plant molecular biology · 2013Article
- Research on plants for the understanding of diseases of nuclear and mitochondrial origin.Journal of biomedicine & biotechnology · 2012Review
- Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation.Annals of botany · 2011Review
- Characterization of Brca2-deficient plants excludes the role of NHEJ and SSA in the meiotic chromosomal defect phenotype.PloS one · 2011Article
- Preferential repair of the transcribed DNA strand in plants.Frontiers in plant science · 2011Article
- Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair.Journal of nucleic acids · 2010Article
- Replication stress leads to genome instabilities in Arabidopsis DNA polymerase delta mutants.The Plant cell · 2009Article
- Overexpression of Arabidopsis damaged DNA binding protein 1A (DDB1A) enhances UV tolerance.Plant molecular biology · 2009Article
- ERCC1/XPF protects short telomeres from homologous recombination in Arabidopsis thaliana.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultraviolet radiation induces DNA damage products, largely in the form of pyrimidine dimers, that are both toxic and mutagenic. In most organisms, including Arabidopsis, these lesions are repaired both through a dimer-specific photoreactivation mechanism and through a less efficient light-independent mechanism. Several mutants defective in this "dark repair" pathway have been previously described. The mechanism of this repair has not been elucidated, but is thought to be homologous to the nucleotide excision repair mechanisms found in other eukaryotes. Here we report the complementation of the Arabidopsis uvh1 dark repair mutant with the Arabidopsis homolog of the yeast nucleotide excision repair gene RAD1, which encodes one of the subunits of the 5'-repair endonuclease. The uvh1-2 mutant allele carries a glycine-->aspartate amino acid change that has been previously identified to produce a null allele of RAD1 in yeast. Although Arabidopsis homologs of genes involved in nucleotide excision repair are readily identified by searching the genomic database, it has not been established that these homologs are actually required for dark repair in plants. The complementation of the Arabidopsis uvh1 mutation with the Arabidopsis RAD1 homolog clearly demonstrates that the mechanism of nucleotide excision repair is conserved among the plant, animal, and fungal kingdoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.