ArticleBritish journal of cancer2000
Overexpression of melanoma inhibitory activity (MIA) enhances extravasation and metastasis of A-mel 3 melanoma cells in vivo.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Endothelial activation during the diapedesis of cancer cells: between the kiss of death and therapeutic breakthrough.Cellular & molecular biology letters · 2025Review
- CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.JCI insight · 2024Article
- CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC.bioRxiv : the preprint server for biology · 2024Article
- Review
- Emerging Biomarkers in Cutaneous Melanoma.Molecular diagnosis & therapy · 2018Review
- Diagnostic and prognostic biomarkers in melanoma.The Journal of clinical and aesthetic dermatology · 2014Review
- Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion.Nature genetics · 2013Article
- Multivariate Analysis of the Survival Rate for Treatment Modalities in Incurable Stage IV Colorectal Cancer.Journal of the Korean Society of Coloproctology · 2012Article
- Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition.PloS one · 2012Article
- Circulating serologic and molecular biomarkers in malignant melanoma.Mayo Clinic proceedings · 2011Review
- Increased potency of the PHSCN dendrimer as an inhibitor of human prostate cancer cell invasion, extravasation, and lung colony formation.Clinical & experimental metastasis · 2010Article
- Misexpression of MIA disrupts lung morphogenesis and causes neonatal death.Developmental biology · 2008Article
- Stepping out of the flow: capillary extravasation in cancer metastasis.Clinical & experimental metastasis · 2008Review
- Survival benefit in patients after palliative resection vs non-resection colon cancer surgery.World journal of gastroenterology · 2006Article
- Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells.Cancer cell international · 2005Article
- Article
- GFP-transfected tumor cells are useful in examining early metastasis in vivo, but immune reaction precludes long-term tumor development studies in immunocompetent mice.Clinical & experimental metastasis · 2003Article
- Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice.Molecular and cellular biology · 2002Article
- Solution structure and dynamics of melanoma inhibitory activity protein.Journal of biomolecular NMR · 2002Article
- Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The secreted MIA protein is strongly expressed by advanced primary and metastatic melanomas but not in normal melanocytes. Previous studies have shown that MIA serum levels correlate with clinical tumour progression in melanoma patients. To provide direct evidence that MIA plays a role in metastasis of malignant melanomas, A-mel 3 hamster melanoma cells were transfected with sense- and antisense rhMIA cDNA and analysed subsequently for changes in their tumorigenic and metastatic potential. Enforced expression of MIA in A-mel 3 cells significantly increased their metastatic potential without affecting primary tumour growth, cell proliferation or apoptosis rate in hamsters, compared with control or antisense transfected cells. Additionally, MIA overexpressing transfectants showed a higher rate of both tumour cell invasion and extravasation. Cells transfected with MIA antisense generally exerted an opposite response. The above changes in function attributed to the expression of MIA may underlie the contribution of MIA to the malignant phenotype.
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