ArticleProceedings of the National Academy of Sciences of the United States of America2000
Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 76 citations in OpenAlex.
- Overexpression of GDP dissociation inhibitor 1 gene associates with the invasiveness and poor outcomes of colorectal cancer.Bioengineered · 2021Article
- Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages.BMC genomics · 2021Article
- Article
- MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors.Experimental eye research · 2015Article
- Binocular pattern deprivation interferes with the expression of proteins involved in primary visual cortex maturation in the cat.Molecular brain · 2015Article
- Proteomic study of retinal proteins associated with transcorneal electric stimulation in rats.Journal of ophthalmology · 2015Article
- Altered short-term plasticity in the prefrontal cortex after early life seizures.Neurobiology of disease · 2013Article
- Sporadic Creutzfeldt-Jakob disease subtype-specific alterations of the brain proteome: impact on Rab3a recycling.Proteomics · 2012Article
- Integrative proteomic analysis of the nucleus accumbens in rhesus monkeys following cocaine self-administration.Molecular psychiatry · 2010Article
- Cognitive impairment in Gdi1-deficient mice is associated with altered synaptic vesicle pools and short-term synaptic plasticity, and can be corrected by appropriate learning training.Human molecular genetics · 2009Article
- Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves.Molecular pain · 2008Article
- Differential dynamics of Rab3A and Rab27A on secretory granules.Journal of cell science · 2007Article
- Therapeutic intervention based on protein prenylation and associated modifications.Nature chemical biology · 2006Review
- Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Modulation of gene expression in MHCC97 cells by interferon alpha.World journal of gastroenterology · 2005Article
- Interferon alpha 2a down-regulates VEGF expression through PI3 kinase and MAP kinase signaling pathways.Journal of cancer research and clinical oncology · 2005Article
- Rab3A negatively regulates activity-dependent modulation of exocytosis in bovine adrenal chromaffin cells.The Journal of physiology · 2004Article
- Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex.The EMBO journal · 2002Article
- A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction.Molecular biology of the cell · 2001Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rab GDP dissociation inhibitor alpha (Rab GDIalpha) is a regulator of the Rab small G proteins implicated in neurotransmission, and mutations of Rab GDIalpha cause human X-linked mental retardation associated with epileptic seizures. In Rab GDIalpha-deficient mice, synaptic potentials in the CA1 region of the hippocampus displayed larger enhancement during repetitive stimulation, which was apparently opposite to the phenotype of Rab3A-deficient mice. Furthermore, the Rab GDIalpha-deficient mice showed hypersensitivity to bicuculline, an inducer of epileptic seizures. These results suggest that Rab GDIalpha plays a specialized role in Rab3A recycling to suppress hyperexcitability via modulation of presynaptic forms of plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.