ArticleProceedings of the National Academy of Sciences of the United States of America2000
Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 83 citations in OpenAlex.
- Breast cancer, viruses, and human leukocyte antigen (HLA).Scientific reports · 2024Article
- Immunogenetic Profiles and Associations of Breast, Cervical, Ovarian, and Uterine Cancers.Cancer informatics · 2023Article
- Immunotherapy: Constructive Approach for Breast Cancer Treatment.Breast cancer (Dove Medical Press) · 2023Review
- Association of HLA-A, B, and C alleles and cancer susceptibility in 179 solid malignancies.American journal of translational research · 2023Article
- Article
- Pan-cancer association of HLA gene expression with cancer prognosis and immunotherapy efficacy.British journal of cancer · 2021Article
- Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso.Open life sciences · 2021Article
- A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck.Cancer research · 2020Article
- Article
- Association between DLA-DRB1.2 allelic diversity and development of mammary gland tumors in dogs.Acta veterinaria Scandinavica · 2019Article
- Bioinformatic profiling of prognosis-related genes in the breast cancer immune microenvironment.Aging · 2019Article
- Mouse mammary tumor viral env sequences are not present in the human genome but are present in breast tumors and normal breast tissues.Virus research · 2019Article
- Tumor mutation burden and recurrent tumors in hereditary lung cancer.Cancer medicine · 2019Article
- The plasma peptides of breast versus ovarian cancer.Clinical proteomics · 2019Article
- Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Molecular Signatures of Human Regulatory T Cells in Colorectal Cancer and Polyps.Frontiers in immunology · 2017Article
- Inference of high resolution HLA types using genome-wide RNA or DNA sequencing reads.BMC genomics · 2014Article
- Comparison of immunity in mice cured of primary/metastatic growth of EMT6 or 4THM breast cancer by chemotherapy or immunotherapy.PloS one · 2014Article
- Downregulation of CD99 and upregulation of human leukocyte antigen class II promote tumor aggravation and poor survival in patients with osteosarcomas.OncoTargets and therapy · 2014Article
- Cure of metastatic growth of EMT6 tumor cells in mice following manipulation of CD200:CD200R signaling.Breast cancer research and treatment · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumors are believed to emerge only when immune surveillance fails. We wished to ascertain whether the failure to inherit putative protective alleles of HLA class II genes is linked to the development of breast cancer. We molecularly typed HLA DPB1, DQB1, DRB1, and DRB3 alleles in 176 Caucasian women diagnosed with early-onset breast cancer and in 215 ethnically matched controls. HLA DQB*03032 was identified in 7% of controls but in no patients with early-onset breast cancer (P = 0.0001). HLA DRB1*11 alleles were also significantly overrepresented (P < 0.0001) in controls (16. 3%) as compared with patients with early-onset breast cancer (3.5%). HLA DQB*03032 and HLA DRB1*11 alleles may have a protective role in human breast cancer.
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