ArticleProceedings of the National Academy of Sciences of the United States of America2000
RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- BARTsc identifies key transcriptional regulators from single-cell omics data.bioRxiv : the preprint server for biology · 2026Article
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- PD-L1- and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease.JCI insight · 2019Article
- Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.Nature communications · 2018Article
- NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms.Blood reviews · 2017Review
- Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin.Cell death & disease · 2015Article
- The Possible Future Roles for iPSC-Derived Therapy for Autoimmune Diseases.Journal of clinical medicine · 2015Review
- Technical Advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells.Journal of leukocyte biology · 2015Article
- Regulation of NF-κB by TNF family cytokines.Seminars in immunology · 2014Review
- Aryl hydrocarbon receptor signaling regulates NF-κB RelB activation during dendritic-cell differentiation.Immunology and cell biology · 2013Article
- Dendritic cells and the promise of antigen-specific therapy in rheumatoid arthritis.Arthritis research & therapy · 2013Review
- Identification of human metapneumovirus-induced gene networks in airway epithelial cells by microarray analysis.Virology · 2008Article
- Inhibition of NF-kappa B during human dendritic cell differentiation generates anergy and regulatory T-cell activity for one but not two human leukocyte antigen DR mismatches.Human immunology · 2007Article
- Regulation of RelB expression during the initiation of dendritic cell differentiation.Molecular and cellular biology · 2005Article
- Protein kinase C blockade inhibits differentiation of myeloid blasts into dendritic cells by calcium ionophore A23187.International journal of hematology · 2005Article
- Rheumatoid arthritis synovium contains plasmacytoid dendritic cells.Arthritis research & therapy · 2005Article
- Dexamethasone prevents interleukin-1beta-induced nuclear factor-kappaB activation by upregulating IkappaB-alpha synthesis, in lymphoblastic cells.Mediators of inflammation · 2003Article
- RelB nuclear translocation mediated by C-terminal activator regions of Epstein-Barr virus-encoded latent membrane protein 1 and its effect on antigen-presenting function in B cells.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice with targeted RelB mutations demonstrated an essential role for RelB in immune responses and in myeloid dendritic cell differentiation. Human studies suggested a more global transcriptional role in antigen presentation. Burkitt lymphoma cell lines were used as a model to examine the role of RelB in antigen presentation. After transient transfection of BJAB with RelB, strong nuclear expression of RelB-p50 heterodimers was associated with increased APC function and expression of CD40 and MHC class I. Antisense RelB in DG75 reduced antigen-presenting capacity and CD40-mediated up-regulation of MHC molecules. The data indicate that RelB transcriptional activity directly affects antigen presentation and CD40 synthesis. Stimulation of RelB transcriptional activity may provide a positive feedback loop for facilitating productive APC/T cell interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.