ArticleNucleic acids research2000
Cell cycle-independent removal of UV-induced pyrimidine dimers from the promoter and the transcription initiation domain of the human CDC2 gene.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Mechanisms of UV-induced mutations and skin cancer.Genome instability & disease · 2020Article
- Article
- Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes.Nature · 2016Article
- DNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes.Nucleic acids research · 2015Article
- Persistently stalled replication forks inhibit nucleotide excision repair in trans by sequestering Replication protein A.Nucleic acids research · 2014Article
- High-resolution characterization of CPD hotspot formation in human fibroblasts.Nucleic acids research · 2014Article
- In situ analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra.Journal of the American Chemical Society · 2012Article
- Measuring the formation and repair of UV damage at the DNA sequence level by ligation-mediated PCR.Methods in molecular biology (Clifton, N.J.) · 2012Article
- UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2012Review
- Investigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells.PloS one · 2010Article
- ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Dissecting transcription-coupled and global genomic repair in the chromatin of yeast GAL1-10 genes.The Journal of biological chemistry · 2004Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To assess whether removal of UV-induced cyclobutane pyrimidine dimers (CPDs) occurs with equal efficiency at different stages of the cell cycle in a cell cycle-regulated gene, we have analyzed repair of CPDs, following a single dose of UV, in normal human fibroblasts that were synchronized in either G(0) or S phase. Based on a single nucleotide resolution analysis, we established a detailed map of DNA repair rates along the promoter region and the transcription initiation area of the human CDC2 gene. The promoter of this gene is covered by an array of sequence-specific transcription factors located between nt -280 and -9 relative to the major transcription start site. In both quiescent and S phase-synchronized fibroblasts the majority of these sequences were poorly repaired even after 24 h, probably as a result of the constitutive binding of transcription factors throughout the cell cycle. A domain of fast repair was found at sequences surrounding the transcription initiation site and continuing downstream for approximately 80 nt. CPD removal from this domain was preferential in both quiescent and proliferating fibroblasts, despite lower levels of global genome repair and a lack of CDC2 transcription in quiescent cells. We suggest that sequences involved in transcription initiation may be book-marked for efficient repair throughout the cell cycle, even when the gene is temporarily not expressed.
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