ArticleBiophysical journal2000
The noise of membrane capacitance measurements in the whole-cell recording configuration.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Measurements of Exocytosis by Capacitance Recordings and Calcium Uncaging in Mouse Adrenal Chromaffin Cells.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Scientist and data architect collaborate to curate and archive an inner ear electrophysiology data collection.PloS one · 2019Article
- Reconstruction of membrane current by deconvolution and its application to membrane capacitance measurements in cardiac myocytes.PloS one · 2017Article
- Carbon nanoelectrodes for single-cell probing.Nanotechnology · 2015Article
- Electrical detection of cellular penetration during microinjection with carbon nanopipettes.Nanotechnology · 2014Article
- Dynamin and myosin regulate differential exocytosis from mouse adrenal chromaffin cells.Cellular and molecular neurobiology · 2010Review
- Differential effects of lysophospholipids on exocytosis in rat PC12 cells.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Individual calcium syntillas do not trigger spontaneous exocytosis from nerve terminals of the neurohypophysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- PKC epsilon facilitates recovery of exocytosis after an exhausting stimulation.Pflugers Archiv : European journal of physiology · 2009Article
- Roles of cholesterol in vesicle fusion and motion.Biophysical journal · 2009Article
- Cortical F-actin, the exocytic mode, and neuropeptide release in mouse chromaffin cells is regulated by myristoylated alanine-rich C-kinase substrate and myosin II.Molecular biology of the cell · 2009Article
- Dynamin I plays dual roles in the activity-dependent shift in exocytic mode in mouse adrenal chromaffin cells.Archives of biochemistry and biophysics · 2008Article
- Myosin II activation and actin reorganization regulate the mode of quantal exocytosis in mouse adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Differential effects of ceramide species on exocytosis in rat PC12 cells.Experimental brain research · 2007Article
- Physiological stimulation regulates the exocytic mode through calcium activation of protein kinase C in mouse chromaffin cells.The Biochemical journal · 2006Article
- Voltage-dependent capacitance of human embryonic kidney cells.Physical review. E, Statistical, nonlinear, and soft matter physics · 2006Article
- An improved method for real-time monitoring of membrane capacitance in Xenopus laevis oocytes.Biophysical journal · 2002Article
- Robust, high-resolution, whole cell patch-clamp capacitance measurements using square wave stimulation.Biophysical journal · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-resolution measurement of membrane capacitance in the whole-cell-recording configuration can be used to detect small changes in membrane surface area that accompany exocytosis and endocytosis. We have investigated the noise of membrane capacitance measurements to determine the fundamental limits of resolution in actual cells in the whole-cell mode. Two previously overlooked sources of noise are particularly evident at low frequencies. The first noise source is accompanied by a correlation between capacitance estimates, whereas the second noise source is due to "1/f-like" current noise. An analytic expression that summarizes the noise from thermal and 1/f sources is derived, which agrees with experimental measurements from actual cells over a large frequency range. Our results demonstrate that the optimal frequencies for capacitance measurements are higher than previously believed. Finally, we demonstrate that the capacitance noise at high frequencies can be reduced by compensating for the voltage drop of the sine wave across the series resistance.
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