ArticleBiophysical journal2000
Modeling concurrent binding of multiple molecular species in cell adhesion.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity.Nature communications · 2022Article
- The kinetics of E-selectin- and P-selectin-induced intermediate activation of integrin αLβ2 on neutrophils.Journal of cell science · 2021Article
- PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition.Nature communications · 2021Article
- Recent Advances and Prospects in the Research of Nascent Adhesions.Frontiers in physiology · 2020Review
- E-selectin-mediated rolling facilitates pancreatic cancer cell adhesion to hyaluronic acid.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Adhesion frequency assay for in situ kinetics analysis of cross-junctional molecular interactions at the cell-cell interface.Journal of visualized experiments : JoVE · 2011Article
- Determining beta2-integrin and intercellular adhesion molecule 1 binding kinetics in tumor cell adhesion to leukocytes and endothelial cells by a gas-driven micropipette assay.The Journal of biological chemistry · 2011Article
- Article
- Two-dimensional kinetics of beta 2-integrin and ICAM-1 bindings between neutrophils and melanoma cells in a shear flow.American journal of physiology. Cell physiology · 2008Article
- Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region.The Journal of biological chemistry · 2008Article
- Probabilistic modeling of rosette formation.Biophysical journal · 2006Article
- Concurrent binding to multiple ligands: kinetic rates of CD16b for membrane-bound IgG1 and IgG2.Biophysical journal · 2000Article
- Concurrent and independent binding of Fcgamma receptors IIa and IIIb to surface-bound IgG.Biophysical journal · 2000Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Cell adhesion provides not only physical linkage but also communication between the cell and its environment. As such, it is important to many cellular functions. Recently, the probability distribution of forming a low number of specific adhesive bonds in a short-duration contact has been described (Chesla et al., Biophys. J. , 1998, 75:1553-1572). This model assumes that binding occurs between a single receptor species and a single ligand species. However, cell adhesion molecules rarely work alone in physiological settings. To account for these in vivo situations, we extended the previous model to include concurrent interactions of multiple receptor-ligand species, introducing the concept of independent binding. Closed-form solutions have been obtained for cases where competition is absent or can be neglected. In two companion papers (Williams et al., Biophys. J., 2000, 79:1858-1866; 2000, 79:1867-1875), the model developed herein has been applied to analyze two sets of experiments designed such that the validity of the theory was also tested.
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Registered trials
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