ArticleBiophysical journal2000
Dynamics of the mitochondrial reticulum in live cells using Fourier imaging correlation spectroscopy and digital video microscopy.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes.Biology open · 2017Article
- Mitochondrial dynamics in heart cells: very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non beating Hl-1 cells.Journal of bioenergetics and biomembranes · 2009Article
- Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II.The Journal of cell biology · 2007Article
- Translational diffusion of fluorescent proteins by molecular fourier imaging correlation spectroscopy.Biophysical journal · 2006Article
- k-Space image correlation spectroscopy: a method for accurate transport measurements independent of fluorophore photophysics.Biophysical journal · 2006Article
- Cytoskeletal-assisted dynamics of the mitochondrial reticulum in living cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
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Authors and funding
3 authors.
Funding
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Abstract
We report detailed studies of the dynamics of the mitochondrial reticulum in live cells using two independent experimental techniques: Fourier imaging correlation spectroscopy and digital video fluorescence microscopy. When both methods are used to study the same system, it is possible to directly compare measurements of preaveraged statistical dynamical quantities with their microscopic counterparts. This approach allows the underlying mechanism of the observed rates to be determined. Our results indicate that the dynamics of the reticulum structure is composed of two independent contributions, each important on very different time and length scales. During short time intervals (1-15 sec), local regions of the reticulum primarily undergo constrained thermally activated motion. During long time intervals (>15 sec), local regions of the reticulum undergo long-range "jump" motions that are associated with the action of cytoskeletal filaments. Although the frequency of the jumps depend on the physiological state of the cells, the average jump distance ( approximately 0.8 microm) is unaffected by metabolic activity. During short time intervals, the dynamics appear to be spatially heterogeneous, whereas the cumulative effect of the infrequent jumps leads to the appearance of diffusive motion in the limit of long time intervals.
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