ArticleThe Biochemical journal2000
Tyrosine kinases activate store-mediated Ca2+ entry in human platelets through the reorganization of the actin cytoskeleton.
Article in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
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- Crocin prevents sesamol-induced oxidative stress and apoptosis in human platelets.Journal of thrombosis and thrombolysis · 2014Trial
- Alleviation of viper venom induced platelet apoptosis by crocin (Crocus sativus): implications for thrombocytopenia in viper bites.Journal of thrombosis and thrombolysis · 2013Trial
- Involvement of stanniocalcins in the deregulation of glycaemia in obese mice and type 2 diabetic patients.Journal of cellular and molecular medicine · 2018Article
- The functions of store-operated calcium channels.Biochimica et biophysica acta. Molecular cell research · 2017Review
- A Real-Time Monitoring System to Assess the Platelet Aggregatory Capacity of Components of a Tissue-Engineered Blood Vessel Wall.Tissue engineering. Part C, Methods · 2016Article
- Propensity of crocin to offset Vipera russelli venom induced oxidative stress mediated neutrophil apoptosis: a biochemical insight.Cytotechnology · 2016Article
- Evaluation of the antiaggregant activity of ascorbyl phenolic esters with antioxidant properties.Journal of physiology and biochemistry · 2015Article
- Enhanced CaJournal of nanomaterials · 2013Article
- Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Crocin, a dietary additive protects platelets from oxidative stress-induced apoptosis and inhibits platelet aggregation.Molecular and cellular biochemistry · 2013Article
- Protein complex immunological separation assay (ProCISA): a technique for investigating single protein properties.Journal of physiology and biochemistry · 2008Article
- Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases.The Journal of cell biology · 2007Article
- Involvement of Src kinases and PLCgamma2 in clot retraction.Thrombosis research · 2007Article
- A role for 5,6-epoxyeicosatrienoic acid in calcium entry by de novo conformational coupling in human platelets.The Journal of physiology · 2006Article
- 2-Benzyloxybenzaldehyde inhibits formyl peptide-stimulated increase in intracellular Ca2+ in neutrophils mainly by blocking Ca2+ entry.Naunyn-Schmiedeberg's archives of pharmacology · 2004Article
- A role for SNAP-25 but not VAMPs in store-mediated Ca2+ entry in human platelets.The Journal of physiology · 2004Article
- Evidence for secretion-like coupling involving pp60src in the activation and maintenance of store-mediated Ca2+ entry in mouse pancreatic acinar cells.The Biochemical journal · 2003Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have recently reported that store-mediated Ca(2+) entry in platelets is likely to be mediated by a reversible trafficking and coupling of the endoplasmic reticulum with the plasma membrane, a model termed 'secretion-like coupling'. In this model the actin cytoskeleton plays a key regulatory role. Since tyrosine kinases have been shown to be important for Ca(2+) entry in platelets and other cells, we have now investigated the possible involvement of tyrosine kinases in the secretion-like-coupling model. Treatment of platelets with thrombin or thapsigargin induced actin polymerization by a calcium-independent pathway. Methyl 2,5-dihydroxycinnamate, a tyrosine kinase inhibitor, prevented thrombin- or thapsigargin-induced actin polymerization. The effects of tyrosine kinases in store-mediated Ca(2+) entry were found to be entirely dependent on the actin cytoskeleton. PP1, an inhibitor of the Src family of proteins, partially inhibited store-mediated Ca(2+) entry. In addition, depletion of intracellular Ca(2+) stores stimulated cytoskeletal association of the cytoplasmic tyrosine kinase pp60(src), a process that was sensitive to treatment with cytochalasin D and PP1, but not to inhibition of Ras proteins using prenylcysteine analogues. Finally, combined inhibition of both Ras proteins and tyrosine kinases resulted in complete inhibition of Ca(2+) entry, suggesting that these two families of proteins have independent effects in the activation of store-mediated Ca(2+) entry in human platelets.
Indexed as
Identifiers
11023829PMC1221379W2064583017What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.