ArticleJournal of psychiatry & neuroscience : JPN2000
Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts.
Article in Journal of psychiatry & neuroscience : JPN, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Lysophosphatidic Acid (LPA) and Its Receptors in Mood Regulation: A Systematic Review of the Molecular Mechanisms and Therapeutic Potential.International journal of molecular sciences · 2024Pooled it
- Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis.Molecular psychiatry · 2022Pooled it
- Association between serum lipid concentrations and attempted suicide in patients with major depressive disorder: A meta-analysis.PloS one · 2020Pooled it
- Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies.Journal of psychiatry & neuroscience : JPN · 2016Pooled it
- Potential preventive effects of forest bathing/Shinrin-yoku on depressive symptoms: a narrative review of mechanistic evidence.Environmental health and preventive medicine · 2026Review
- Serotonin and neurofilament light chain in alcohol-related suicide: Preliminary case observations.Brain, behavior, & immunity - health · 2025Article
- Comparison of the Kynurenine/Tryptophan Ratio with the Beck Suicide Intent Scale in Patients Admitted to the Emergency Department Due to Suicide Attempt.Journal of clinical medicine · 2025Article
- Impacts of Forest Bathing (Shinrin-Yoku) in Female Participants with Depression/Depressive Tendencies.Diseases (Basel, Switzerland) · 2025Article
- Is forest bathing a panacea for mental health problems? A narrative review.Frontiers in public health · 2025Review
- Plasma Apo-E mediated corticospinal tract abnormalities and suicidality in patients with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions.Biomedicines · 2023Article
- Effects of forest bathing (shinrin-yoku) on serotonin in serum, depressive symptoms and subjective sleep quality in middle-aged males.Environmental health and preventive medicine · 2022Article
- Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders.Cells · 2020Review
- Lipid-Lowering Drug Effects Beyond the Cardiovascular System: Relevance for Neuropsychiatric Disorders.The international journal of neuropsychopharmacology · 2018Article
- Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population.BMC psychiatry · 2018Article
- The Role of Lipid Biomarkers in Major Depression.Healthcare (Basel, Switzerland) · 2017Review
- The association between altered lipid profile and suicide attempt among Tunisian patients with schizophrenia.Annals of general psychiatry · 2016Article
- The role of the kynurenine pathway in suicidality in adolescent major depressive disorder.Psychiatry research · 2015Article
- Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology.PloS one · 2015Article
- Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions.BMC neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine if there is a relation to low serum cholesterol, lipoprotein, serotonin or tryptophan levels in patients with depression who have recently attempted suicide.
designBiochemical and behavioural study.
settingInpatient and outpatient treatment at the Instituto Mexicano de Psiquiatría.
participantsThirty-three patients with a diagnosis of major depressive episode. Eighteen of these patients had attempted suicide in the month before the start of the study; 15 patients had never attempted suicide. OUTCOME MEASURES: Serum levels of total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, serotonin (5-HT) and tryptophan. Scores on Hamilton Depression Rating Scale, Carroll Depression Rating Scale, Beck Hopelessness Scale and Beck Suicide Attempt Severity Scale.
resultsThere were no significant differences between patients who had attempted suicide and those who had not in terms of serum cholesterol, HDL, LDL and triglyceride levels. Serum levels of 5-HT and tryptophan were significantly lower in patients with depression who had a recent suicide attempt than in those patients who had never attempted suicide. A comparison of patients not taking antidepressant medication found serum 5-HT levels to be more than 3 times lower in those patients with a recent suicide attempt than in patients with no history of suicide attempt.
conclusionsThe study found no difference in lipid profiles between patients who had attempted suicide and those who had not. Low serum levels of 5-HT may increase the risk of suicide attempt in patients who are depressed.
Indexed as
Identifiers
11022402PMC1407732W115928149What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.