ArticleJournal of psychiatry & neuroscience : JPN2000
Association and linkage studies of candidate genes involved in GABAergic neurotransmission in lithium-responsive bipolar disorder.
Article in Journal of psychiatry & neuroscience : JPN, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
- The Genetics of Response to and Side Effects of Lithium Treatment in Bipolar Disorder: Future Research Perspectives.Frontiers in pharmacology · 2021Review
- The Role of Pharmacogenomics in Bipolar Disorder: Moving Towards Precision Medicine.Molecular diagnosis & therapy · 2018Review
- Pharmacogenomics in psychiatry: the relevance of receptor and transporter polymorphisms.British journal of clinical pharmacology · 2014Review
- Response to treatment in bipolar disorder.Current opinion in psychiatry · 2011Review
- Pharmacogenomics of mood stabilizers in the treatment of bipolar disorder.Human genomics and proteomics : HGP · 2010Article
- The promise and reality of pharmacogenetics in psychiatry.The Psychiatric clinics of North America · 2010Review
- Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility.BMC medical genetics · 2008Article
- The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions.Molecular psychiatry · 2008Review
- Pharmacogenetics and bipolar disorder.The pharmacogenomics journal · 2004Review
- Long-term responsiveness to lithium as a pharmacogenetic outcome variable: treatment and etiologic implications.Current psychiatry reports · 2003Review
- GABAergic dysfunction in mood disorders.Molecular psychiatry · 2003Review
- Pharmacogenetics of bipolar disorder.Current psychiatry reports · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test for genetic linkage and association with GABAergic candidate genes in lithium-responsive bipolar disorder.
designPolymorphisms located in genes that code for GABRA3, GABRA5 and GABRB3 subunits of the GABAA receptor were investigated using association and linkage strategies.
participantsA total of 138 patients with bipolar 1 disorder with a clear response to lithium prophylaxis, selected from specialized lithium clinics in Canada and Europe that are part of the International Group for the Study of Lithium-Treated Patients, and 108 psychiatrically healthy controls. Families of 24 probands were suitable for linkage analysis. OUTCOME MEASURES: The association between the candidate genes and patients with bipolar disorder versus that of controls and genetic linkage within families.
resultsThere was no significant association or linkage found between lithium-responsive bipolar disorder and the GABAergic candidate genes investigated.
conclusionsThis study does not support a major role for the GABAergic candidate genes tested in lithium-responsive bipolar disorder.
Indexed as
Identifiers
11022400PMC1407742W2097436104What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.