ArticleThe American journal of pathology2000
p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 81 citations in OpenAlex.
- Do Neurotrophins Connect Neurological Disorders and Heart Diseases?Biomolecules · 2021Review
- Brain-Derived Neurotrophic Factor Expression and Signaling in Different Perivascular Adipose Tissue Depots of Patients With Coronary Artery Disease.Journal of the American Heart Association · 2021Article
- Soluble Tumor Necrosis Factor Receptor 1 is Associated With Cardiovascular Risk in Persons With Coronary Artery Calcium Score of Zero.Pathogens & immunity · 2021Article
- Serum Levels of BDNF in Cardiovascular Protection and in Response to Exercise.Arquivos brasileiros de cardiologia · 2020Article
- Recombinant Extracellular Domain (p75ECD) of the Neurotrophin Receptor p75 Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting the p-JNK/Caspase-3 Signaling Pathway in Rat Microvascular Pericytes.Journal of the American Heart Association · 2020Article
- Agonist-Biased Signaling via Matrix Metalloproteinase-9 Promotes Extracellular Matrix Remodeling.Cells · 2018Review
- MicroRNA-296: a promising target in the pathogenesis of atherosclerosis?Molecular medicine (Cambridge, Mass.) · 2018Review
- [Research progress of P75 neurotrophin receptor and new idea of nonunion treatment].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2017Review
- Spinal Plasticity and Behavior: BDNF-Induced Neuromodulation in Uninjured and Injured Spinal Cord.Neural plasticity · 2016Review
- Brain-derived neurotrophic factor and its clinical implications.Archives of medical science : AMS · 2015Article
- Imbalance of the Nerve Growth Factor and Its Precursor: Implication in Diabetic Retinopathy.Journal of clinical & experimental ophthalmology · 2015Article
- Neurotrophins are expressed in giant cell arteritis lesions and may contribute to vascular remodeling.Arthritis research & therapy · 2014Article
- Brain-derived neurotrophic factor in the airways.Pharmacology & therapeutics · 2014Review
- Sortilin expression is essential for pro-nerve growth factor-induced apoptosis of rat vascular smooth muscle cells.PloS one · 2014Article
- ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation.The Journal of experimental medicine · 2012Article
- Brain-derived neurotrophic factor increases expression of MnSOD in human circulating angiogenic cells.Microvascular research · 2012Article
- Experimental verification of a predicted intronic microRNA in human NGFR gene with a potential pro-apoptotic function.PloS one · 2012Article
- Chronic nerve growth factor exposure increases apoptosis in a model of in vitro induced conjunctival myofibroblasts.PloS one · 2012Article
- Brain-derived neurotrophic factor gene Val66Met polymorphism modulates reversible cerebral vasoconstriction syndromes.PloS one · 2011Article
- Neurotrophins in lung health and disease.Expert review of respiratory medicine · 2010Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The development of atherosclerotic lesions results from aberrant cell migration, proliferation, and extracellular matrix production. In advanced lesions, however, cellular apoptosis, leading to lesion remodeling, predominates. During lesion formation, the neurotrophins and the neurotrophin receptor tyrosine kinases, trks B and C, are induced and mediate smooth muscle cell migration. Here we demonstrate that a second neurotrophin receptor, p75(NTR), is expressed by established human atherosclerotic lesions and late lesions that develop after balloon injury of the rat thoracic aorta. The p75(NTR), a member of the tumor necrosis factor/FAS receptor family, can modulate trk receptor function as well as initiate cell death when expressed in cells of the nervous system that lack kinase-active trk receptors. p75(NTR) expression colocalizes to neointimal cells, which express smooth muscle cell alpha-actin and are expressed by cultured human endarterectomy-derived cells (HEDC). Areas of the plaque expressing p75(NTR) demonstrate increased TUNEL positivity, and HEDC undergo apoptosis in response to the neurotrophins. Finally, neurotrophins also induced apoptosis of a smooth muscle cell line genetically manipulated to express p75(NTR), but lacking trk receptor expression. These studies identify the regulated expression of neurotrophins and p75(NTR) as an inducer of smooth muscle cell apoptosis in atherosclerotic lesions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.