ArticleThe American journal of pathology2000
Prevalence of human papillomavirus DNA in different histological subtypes of cervical adenocarcinoma.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
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Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis.British journal of cancer · 2003Pooled it
- Efficacy of Oral Zinc Sulfate Supplementation on Clearance of Cervical Human Papillomavirus (HPV); A Randomized Controlled Clinical Trial.Asian Pacific journal of cancer prevention : APJCP · 2022Trial
- DNA methylation for cervical cancer screening: a training set in China.Clinical epigenetics · 2020Trial
- Primary Clear Cell Adenocarcinoma of the Cervix: A Series of 12 Cases Without Exposure to Diethylstilbestrol.Cureus · 2025Article
- Epidemiological Profile of HPV Genotypes Among Moroccan Women with High-Grade Squamous Lesions and Invasive Cervical Cancer from Souss-Massa Region.Tropical medicine and infectious disease · 2025Article
- High-risk HPV serotype distribution in cervical cancer: comparative analysis of detection in cervicovaginal secretions and tissue DNA extraction.Ecancermedicalscience · 2025Article
- The immediate risk of cancer and its precursor lesions in women with abnormal cervical glandular cytology.Journal of Cancer · 2025Article
- Prevalence and Pattern of GATA3 Immunohistochemical Expression in Female Genital Tract Adenocarcinomas.Iranian journal of pathology · 2024Article
- A case of coexistent poorly differentiated adenosquamous carcinoma (glassy cell carcinoma), usual-type adenocarcinoma, and squamous cell carcinoma in situ of the cervix.Medical molecular morphology · 2023Article
- Cervical cancer: a tale from HPV infection to PARP inhibitors.Genes & diseases · 2023Review
- Article
- HPV-Negative Adenocarcinomas of the Uterine Cervix: From Molecular Characterization to Clinical Implications.International journal of molecular sciences · 2022Review
- New Insights in the Diagnosis of Rare Adenocarcinoma Variants of the Cervix-Case Report and Review of Literature.Healthcare (Basel, Switzerland) · 2022Article
- Viral Pathogens in Oesophageal and Gastric Cancer.Pathogens (Basel, Switzerland) · 2022Review
- Impact of human papillomavirus vaccine on cervical cancer epidemic: Evidence from the surveillance, epidemiology, and end results program.Frontiers in public health · 2022Article
- Review
- Genomic alterations caused by HPV integration in a cohort of Chinese endocervical adenocarcinomas.Cancer gene therapy · 2021Article
- HPV-Negative Cervical Cancer: A Narrative Review.Diagnostics (Basel, Switzerland) · 2021Review
- Cervical Mesonephric Adenocarcinoma: A Case Report of a Rare Gynecological Tumor from Embryological Remains of the Female Genital Tract.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2021Article
- Squamous intraepithelial lesions (SIL: LSIL, HSIL, ASCUS, ASC-H, LSIL-H) of Uterine Cervix and Bethesda System.CytoJournal · 2021Review
28 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of human papilloma virus (HPV) DNA in different histological subtypes of cervical adenocarcinoma and related tumors was examined using formalin-fixed, paraffin-embedded tissue samples from 105 primary cervical adenocarcinomas and adenosquamous carcinomas. Broad-spectrum HPV DNA amplification and genotyping was performed with the SPF10 primer set and line probe assay (LiPA), respectively. HPV DNA was detected in 82 of 90 (91%) mucinous adenocarcinomas, encompassing endocervical, intestinal, and endometrioid histological subtypes, and in nine of nine adenosquamous tumors (100%). HPV DNA was not detected in any nonmucinous adenocarcinomas including clear cell, serous, and mesonephric carcinomas (0/6). The most common viral types detected in adenocarcinoma were HPV 16 (50%) and HPV 18 (40%), followed by HPV 45 (10%), HPV52 (2%), and HPV 35 (1%). Multiple HPV types were detected in 9.7% of the cases. In conclusion, mucinous adenocarcinomas and adenosquamous carcinomas of the cervix demonstrate a very high prevalence of HPV DNA, similar to that reported for cervical squamous cell carcinoma. Only rare histological variants of cervical adenocarcinoma seem unrelated to HPV infection.
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