ArticleThe Journal of cell biology2000
Dynein, dynactin, and kinesin II's interaction with microtubules is regulated during bidirectional organelle transport.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 58 citations in OpenAlex.
- Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest.Oncogene · 2004Article
- A plant-specific subclass of C-terminal kinesins contains a conserved a-type cyclin-dependent kinase site implicated in folding and dimerization.Plant physiology · 2004Article
- Dynactin polices two-way organelle traffic.The Journal of cell biology · 2003Review
- Colocalisation of the protein tyrosine phosphatases PTP-SL and PTPBR7 with beta4-adaptin in neuronal cells.Histochemistry and cell biology · 2003Article
- A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport.The Journal of cell biology · 2002Article
- Kinesin-II is required for flagellar sensory transduction during fertilization in Chlamydomonas.Molecular biology of the cell · 2002Article
- Interactions and regulation of molecular motors in Xenopus melanophores.The Journal of cell biology · 2002Article
- Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Intraflagellar transport balances continuous turnover of outer doublet microtubules: implications for flagellar length control.The Journal of cell biology · 2001Article
- Self-organization of a radial microtubule array by dynein-dependent nucleation of microtubules.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Cytoplasmic dynein regulation by subunit heterogeneity and its role in apical transport.The Journal of cell biology · 2001Article
- Sorting and directed transport of membrane proteins during development of hippocampal neurons in culture.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Direct visualization of the movement of the monomeric axonal transport motor UNC-104 along neuronal processes in living Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus.The EMBO journal · 2001Article
- The 9 + 2 axoneme anchors multiple inner arm dyneins and a network of kinases and phosphatases that control motility.The Journal of cell biology · 2000Review
Corrections and comments
- Retraction · 2003-02-04Results Not Reproducible ·
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microtubule motors, cytoplasmic dynein and kinesin II, drive pigmented organelles in opposite directions in Xenopus melanophores, but the mechanism by which these or other motors are regulated to control the direction of organelle transport has not been previously elucidated. We find that cytoplasmic dynein, dynactin, and kinesin II remain on pigment granules during aggregation and dispersion in melanophores, indicating that control of direction is not mediated by a cyclic association of motors with these organelles. However, the ability of dynein, dynactin, and kinesin II to bind to microtubules varies as a function of the state of aggregation or dispersion of the pigment in the cells from which these molecules are isolated. Dynein and dynactin bind to microtubules when obtained from cells with aggregated pigment, whereas kinesin II binds to microtubules when obtained from cells with dispersed pigment. Moreover, the microtubule binding activity of these motors/dynactin can be reversed in vitro by the kinases and phosphatase that regulate the direction of pigment granule transport in vivo. These findings suggest that phosphorylation controls the direction of pigment granule transport by altering the ability of dynein, dynactin, and kinesin II to interact with microtubules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.