ArticleThe Journal of cell biology2000
Meiotic telomere protein Ndj1p is required for meiosis-specific telomere distribution, bouquet formation and efficient homologue pairing.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed.
- Stepwise pairing and fast transition regulated by recombination drive meiotic chromosome interactions.Nature communications · 2026Article
- Nucleolar Cdc14 Splitting Reflects Recombination Context and Meiotic Chromosome Dynamics.International journal of molecular sciences · 2026Article
- Telomeres, the nuclear lamina, and membrane remodeling: Orchestrating meiotic chromosome movements.The Journal of cell biology · 2025Review
- Formation and resolution of meiotic chromosome entanglements and interlocks.Journal of cell science · 2024Review
- The Dmc1 recombinase physically interacts with and promotes the meiotic crossover functions of the Mlh1-Mlh3 endonuclease.bioRxiv : the preprint server for biology · 2023Article
- Meiosis in budding yeast.Genetics · 2023Article
- The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing.Frontiers in cell and developmental biology · 2023Review
- Beyond tradition: exploring the non-canonical functions of telomeres in meiosis.Frontiers in cell and developmental biology · 2023Article
- Modeling cell biological features of meiotic chromosome pairing to study interlock resolution.PLoS computational biology · 2022Article
- Review
- Low Female Gametophyte Fertility Contributes to the Low Seed Formation of the Diploid Loquat [Frontiers in plant science · 2022Article
- Article
- The Diverse Cellular Functions of Inner Nuclear Membrane Proteins.Cold Spring Harbor perspectives in biology · 2021Review
- Two telomeric ends of acrocentric chromosome play distinct roles in homologous chromosome synapsis in the fetal mouse oocyte.Chromosoma · 2021Article
- Meiotic Crossover Patterning.Frontiers in cell and developmental biology · 2021Review
- The SUN Domain Proteins OsSUN1 and OsSUN2 Play Critical but Partially Redundant Roles in Meiosis.Plant physiology · 2020Article
- Extranuclear Structural Components that Mediate Dynamic Chromosome Movements in Yeast Meiosis.Current biology : CB · 2020Article
- Telomere-led meiotic chromosome movements: recent update in structure and function.Nucleus (Austin, Tex.) · 2020Review
- SWR1-Independent Association of H2A.Z to the LINC Complex Promotes Meiotic Chromosome Motion.Frontiers in cell and developmental biology · 2020Article
- FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis.Nucleic acids research · 2019Article
39 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
We have investigated the requirements for NDJ1 in meiotic telomere redistribution and clustering in synchronized cultures of Saccharomyces cerevisiae. On induction of wild-type meiosis, telomeres disperse from premeiotic aggregates over the nuclear periphery, and then cluster near the spindle pole body (bouquet arrangement) before dispersing again. In ndj1Delta meiocytes, telomeres are scattered throughout the nucleus and fail to form perinuclear meiosis-specific distribution patterns, suggesting that Ndj1p may function to tether meiotic telomeres to the nuclear periphery. Since ndj1Delta meiocytes fail to cluster their telomeres at any prophase stage, Ndj1p is the first protein shown to be required for bouquet formation in a synaptic organism. Analysis of homologue pairing by two-color fluorescence in situ hybridization with cosmid probes to regions on III, IX, and XI revealed that disruption of bouquet formation is associated with a significant delay (>2 h) of homologue pairing. An increased and persistent fraction of ndj1Delta meiocytes with Zip1p polycomplexes suggests that chromosome polarization is important for synapsis progression. Thus, our observations support the hypothesis that meiotic telomere clustering contributes to efficient homologue alignment and synaptic pairing. Under naturally occurring conditions, bouquet formation may allow for rapid sporulation and confer a selective advantage.
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