ArticleProceedings of the National Academy of Sciences of the United States of America2000
Adaptive regulation of intestinal lysine metabolism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 160 citations in OpenAlex.
- Optimal standardized ileal digestible lysine levels in low-protein diets: Effects on performance of lactating sows and their offspring.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Vanadyl sulfate supplementation alters the intestinal microbiome and bile acid metabolism.Toxicology and applied pharmacology · 2025Article
- Dietary xylo-oligosaccharides and arabinoxylans improved growth efficiency by reducing gut epithelial cell turnover in broiler chickens.Journal of animal science and biotechnology · 2024Article
- Messages from the Small Intestine Carried by Extracellular Vesicles in Prediabetes: A Proteomic Portrait.Journal of proteome research · 2022Article
- Effects of Dietary Crude Protein Levels on Fecal Crude Protein, Amino Acids Flow Amount, Fecal and Ileal Microbial Amino Acids Composition and Amino Acid Digestibility in Growing Pigs.Animals : an open access journal from MDPI · 2020Article
- Effects of lysine and methionine in a low crude protein diet on the growth performance and gene expression of immunity genes in broilers.Poultry science · 2020Article
- Effects of vitamin B6 on the growth performance, intestinal morphology, and gene expression in weaned piglets that are fed a low-protein diet1.Journal of animal science · 2020Article
- Article
- Identification and Structure-Activity Relationship of Intestinal Epithelial Barrier Function Protective Collagen Peptides from Alaska Pollock Skin.Marine drugs · 2019Article
- Energy metabolism in the intestinal crypt epithelial cells of piglets during the suckling period.Scientific reports · 2018Article
- Energy metabolism in intestinal epithelial cells during maturation along the crypt-villus axis.Scientific reports · 2016Article
- Article
- Lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond.SpringerPlus · 2015Article
- Supplementing monosodium glutamate to partial enteral nutrition slows gastric emptying in preterm pigs(1-3).The Journal of nutrition · 2013Article
- Modulation of the gut microbiota with antibiotic treatment suppresses whole body urea production in neonatal pigs.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- B-vitamin deficiency is protective against DSS-induced colitis in mice.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs.American journal of physiology. Endocrinology and metabolism · 2009Article
- Bicarbonate kinetics and predicted energy expenditure in critically ill children.The American journal of clinical nutrition · 2008Article
- Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabolism of dietary essential amino acids by the gut has a direct effect on their systemic availability and potentially limits growth. We demonstrate that, in neonatal pigs bearing portal and arterial catheters and fed a diet containing 23% protein [high protein (HP) diet], more than half the intake of essential amino acids is metabolized by the portal-drained viscera (PDV). Intraduodenal or i.v. infusions of [U-(13)C]-lysine were used to measure the appearance across and the use of the tracer by the PDV. In HP-fed pigs, lysine use by the PDV was derived almost entirely from the arterial input. In these animals, the small amount of dietary lysine used in first pass was oxidized almost entirely. Even so, intestinal lysine oxidation (24 micromol/kg per h) accounted for one-third of whole-body lysine oxidation (77 micromol/kg per h). Total lysine use by the PDV was not affected by low protein (LP) feeding (HP, 213 micromol/kg per h; LP,186 micromol/kg per h). In LP-fed pigs, the use of lysine by the PDV accounted for more than 75% of its intake. In contrast to HP feeding, both dietary and arterial lysines were used by the PDV of LP-fed pigs in nearly equal amounts. Intestinal lysine oxidation was suppressed completely. We conclude that the PDV are key organs with respect to amino acid metabolism and that the intestines use a disproportionately large amount of the dietary supply of amino acids during protein restriction.
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